We aimed to identify GPCR-related gene (GPCRRG) signatures and develop a novel model to predict OV prognosis analysis, and a prognostic model was constructed. The predictive ability of the model was evaluated by Kaplan-Meier (K-M) survival analysis. K-M analysis of the prognostic model showed that it could differentiate high- and low-risk patients, Conclusions: Our prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for

< GPCR News < GPCRs in Oncology and Immunology Exploration of prognostic and treatment markers in hepatocellular hepatocellular carcinoma (HCC) was elucidated, and GPCR-related genes were employed for building a risk-score model for the prognosis and treatment efficacy prediction of HCC patients. A clinical prediction model on the basis of GPCR-related risk scores was constructed. Conclusions: In this study, an efficient HCC prognostic prediction model was constructed by only GPCR-related

< GPCR News < GPCRs in Oncology and Immunology GPR37 expression as a prognostic marker in gliomas: a explore the relationship between GPR37 gene expression and the clinicopathological factors, patient prognosis significantly higher in the glioma tissues compared to the normal brain tissues, and was linked to poor prognosis Conclusion: GPR37 had diagnostic and prognostic value in glioma. Yanbin Ke , Zhaotao Wang , Yezhong Wang Tags GPR37 , M2 macrophages , glioma , immune infiltration , prognosis

and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic is significantly overexpressed in various types of malignancies, which is associated with the worst prognosis In the Cox proportional hazards model, β2-AR was identified as a prognostic biomarker of OSCC (p = 0.047 Conclusion: β2-AR protein level is identified as an independent significant prognostic factor in patients Mohanty, Rajender Singh, Vijay Kumar, Uma Shankar Singh, Rakesh Kumar Singh Tags GPCR; OSCC; Oral cancer; Prognostic

We investigated the prognostic values of the guanine nucleotide-binding protein G(i) alpha subunit (GNAI association in the tumor microenvironment between the gene expression of GNAI subunit 3 (GNAI3) and a poor prognosis Our findings suggest that the GNAI3 gene holds potential as a prognostic biomarker for GBM. Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy , molecular biomarker , prognosis

GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis were used to evaluate the relationship between clinical characteristics and PAXIP1-AS1 expression, prognostic PAXIP1-AS1 could be a promising prognosis biomarker and response to immunotherapy for OC."

We found several genes that are known PCa prognostic factors or biomarker to be differentially expressed

findings shed light on the potential of non-canonical odorant receptors as therapeutic targets and prognostic

Survival analysis established the clinical prognostic relevance of identified hub genes in cancer.

correlates with survival outcomes and therapy response in ovarian cancer clinical samples, underscoring its prognostic

PR is an important prognostic factor in breast cancer.

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning Published date September 15, 2023 Abstract "The multikinase

GPCR News < GPCRs in Oncology and Immunology SSTR2 positively associates with EGFR and predicts poor prognosis belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis expression of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis expression of EGFR, high coexpression of EGFR and SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis Additionally, SSTR2 has potential as a new biomarker for poor prognosis in NPC patients."

specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis Constructing models of TAMs and LUAD mice, we find that A2aR highly expressed on LUAD cells promotes

cancers, and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis Available structures of the RGS2-Gα complex were used to extract a pharmacophore model for searching

3, 2023 Abstract " Purpose: Peripheral T-cell lymphoma (PTCL) is an aggressive disease with a poor prognosis HH cells, originating from an aggressive cutaneous T-cell lymphoma, were used as an experimental model

June 24, 2024 Abstract "Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease with poor prognosis While the prognosis of colorectal carcinoma (CRC) is better than that of PDAC, it still is the second-leading Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition

tumors, particularly in non-small-cell lung cancer (NSCLC) METHODS: We explored the expression and prognosis We found that elevated GPR37 expression predicts an unfavorable prognosis. (2) It was demonstrated that

To test this, an LFS mouse model (germline Tp53 deletion) with a second floxed allele under the control Preliminary findings indicate that the simultaneous loss of Bai3 and Tp53 expression in our mouse model A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development He is also interested in working on Glioma Brain Organoid models." Before joining UAB as a graduate student, he worked in the EuGEF Research Group to identify novel prognostic

Determine the Signaling Profile of Adhesion GPCR ADGRL1 / Latrophilin-1 Sheila Ribalta-Mena GPR110 modulates of CELSR1, which would be missed in gene expression microarray analyses, we hope to illuminate the prognostic GPR56 in the collecting duct, we generated a collecting duct-specific GPR56 knockout (GPR56CD-KO) mouse model This mouse model will be useful to delineate the collecting duct-specific role of GPR56 for renal function During my graduate studies, using various transgenic mouse models and expertise in intestinal and renal

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling unexpected differences in downstream pathway activation Published date July 16, 2024 Abstract "Mathematical models One promising potential application of such mathematical models is the study of how disease-causing mutations to be useful, but we hypothesized that mathematical modeling could be useful when there is incomplete In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor

< GPCR News < GPCRs in Oncology and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine chromatography-mass spectrometry-based proteomic analysis was performed, and a system pharmacodynamics model Part I described the proteomic workflow and drug effects on the upstream portion of the SPD model related This companion report presents Part II of the SPD model. The SPD model was subsequently incorporated into our previously-established cell cycle model, forming

Several studies have suggested that SCI-IDS is an independent risk factor for poor neurological prognosis immunosuppression in the periphery results in increased susceptibility to infection, leading to poor neurological prognosis

GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models

associated with accelerated progression of glioblastomas, aggressive brain tumors with a generally poor prognosis

Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model clonal-expansion theory of cancer, e.g., as represented in the Moolgavkar-Venzon-Knudsen (MVK) cancer model carcinogenic (e.g., certain asbestos) fibers in humans and experimental animals are thought to involve modes cytotoxicity-associated inflammation, or both, rendering ambiguous expectations concerning the nature of model-implied

G protein signaling (RGS) protein family modulators play essential role within regulating downstream 899 CRC tissues revealed elevated RGS16 levels, correlating with clinicopathological features and CRC prognosis

cancer cell lines and cancer tissues and that coexpression of CXCR4 and HRH1 is associated with poor prognosis