), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation In vitro, SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation

They have participated in various cellular processes such as cell proliferation, migration, apoptosis

protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial smooth muscle proliferation arterial contraction and stimulates signalling pathways that promote vascular smooth muscle cell (VSMC) proliferation GPCR signalling through phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation implicated in controlling various aspects of cellular growth, we examined whether GRK2 could affect VSMC proliferation These data suggest GRK2 expression is essential to facilitate vasoconstrictor-driven VSMC proliferation

Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation However, the pathophysiological role of increased VIPR2 in the proliferation of breast cancer cells remains that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer cell lines, promoted cell proliferation Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation

KS-133, a newly developed VIPR2-selective antagonist peptide, attenuated VIP-induced cell proliferation through the cAMP/PKA/ERK and PI3K/AKT/GSK3β pathways, and mediates the G1/S transition to control cell proliferation Nakazawa , Souichi Yanamoto , Kotaro Tanimoto , Hitoshi Hashimoto , Yukio Ago Tags Cell cycle , Cell proliferation

The study explored the influence of GPR37 on tumor cell proliferation. prognosis. (2) It was demonstrated that GPR37 positively regulates NSCLC cell invasion, migration, and proliferation Conversely, we observed that GPR37 knockdown suppresses NSCLC cell invasion, migration, and proliferation