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36 items found for "Proliferation"
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation In vitro, SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
They have participated in various cellular processes such as cell proliferation, migration, apoptosis
- G protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial ...
protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial smooth muscle proliferation arterial contraction and stimulates signalling pathways that promote vascular smooth muscle cell (VSMC) proliferation GPCR signalling through phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation implicated in controlling various aspects of cellular growth, we examined whether GRK2 could affect VSMC proliferation These data suggest GRK2 expression is essential to facilitate vasoconstrictor-driven VSMC proliferation
- Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
Stimulation of AVPR2 with a selective agonist desmopressin promoted CRPC cell proliferation through cAMP ligand for arginine vasopressin receptors, and knockout of AVP in CRPC cells significantly reduced proliferation
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
investigate the effects that long-term CNO stimulatory culture have on hM3Dq [Ca2+]i signaling dynamics, proliferation repeated CNO stimulation modified the temporal dynamics of hM3Dq [Ca2+]i signaling, increased cell proliferation demonstrated Gαq-G-protein coupled receptor (GPCR)-mediated [Ca2+]i signaling involvement in chondroprogenitor proliferation
- Odorant receptors – a bit of smell for drug discovery
OR function has been implicated in myelogenous leukemia where OR2AT4 activation leads to reduced proliferation assumed to be GPCRs only expressed in prostate tissue, play a role in prostate cancer epithelial cells proliferation In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and Gelis L. et. al 2016) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte proliferation
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after fentanyl
- MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
are key integrated signaling nodes in various biological processes, and both of them regulate cell proliferation
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
They have participated in various cellular processes such as cell proliferation, migration, apoptosis
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
mechanisms and spatial localisation within the cell, is a crucial determinant of cellular responses such as proliferation various pathological conditions, including cancer, aberrant ERK activity can lead to uncontrolled cell proliferation
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
transient receptor potential ankyrin subtype 1 protein (TRPA1) signaling pathways, thereby regulating proliferation
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor cell proliferation
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
STING) signaling pathway has been implicated in organ injuries and its activation inhibits endothelial proliferation
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
effectors recruited by GPCR-bound arrestins are Src family kinases, which regulate cellular growth and proliferation
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
knockout significantly suppressed malignant properties of breast cancer cells, such as inhibition of cell proliferation
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
February 2022 Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with
- Melatonin MT 2 receptor is expressed and potentiates contraction in human airway smooth muscle
Ca2+]i), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation
- 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!
signaling GPCR Binders, Drugs, and more Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
methyladenine or interference of ATG5 or ATG7 attenuated HBx-induced cell cycle acceleration and the subsequent proliferative lysyl oxidase; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MKI67: marker of proliferation
- 📰 GPCR Weekly News - January 2 to 8, 2023
Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation
- 📰 GPCR Weekly News, January 23 to 29, 2023
Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.
- 📰 GPCR Weekly News, January 16 to 22, 2023
Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.
- 📰 GPCR Weekly News, October 16 to 22, 2023
neurodegenerative diseases GPCRs in Neuroscience Primary cilia control oligodendrocyte precursor cell proliferation
- 📰 GPCR Weekly News, July 24 to July 30, 2023
GPCRs Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation
- 📰 GPCR Weekly News, February 26 to March 3, 2024
cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation
- 📰 GPCR Weekly News, June 26 to July 2, 2023
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma