), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation In vitro , SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation

They have participated in various cellular processes such as cell proliferation, migration, apoptosis

protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial smooth muscle proliferation arterial contraction and stimulates signalling pathways that promote vascular smooth muscle cell (VSMC) proliferation GPCR signalling through phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation implicated in controlling various aspects of cellular growth, we examined whether GRK2 could affect VSMC proliferation These data suggest GRK2 expression is essential to facilitate vasoconstrictor-driven VSMC proliferation

Stimulation of AVPR2 with a selective agonist desmopressin promoted CRPC cell proliferation through cAMP ligand for arginine vasopressin receptors, and knockout of AVP in CRPC cells significantly reduced proliferation

non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated

investigate the effects that long-term CNO stimulatory culture have on hM3Dq [Ca2+]i signaling dynamics, proliferation repeated CNO stimulation modified the temporal dynamics of hM3Dq [Ca2+]i signaling, increased cell proliferation demonstrated Gαq-G-protein coupled receptor (GPCR)-mediated [Ca2+]i signaling involvement in chondroprogenitor proliferation

OR function has been implicated in myelogenous leukemia where OR2AT4 activation leads to reduced proliferation assumed to be GPCRs only expressed in prostate tissue, play a role in prostate cancer epithelial cells proliferation In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and Gelis L. et. al 2016) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte proliferation

Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after

the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation

are key integrated signaling nodes in various biological processes, and both of them regulate cell proliferation

They have participated in various cellular processes such as cell proliferation, migration, apoptosis

mechanisms and spatial localisation within the cell, is a crucial determinant of cellular responses such as proliferation various pathological conditions, including cancer, aberrant ERK activity can lead to uncontrolled cell proliferation

transient receptor potential ankyrin subtype 1 protein (TRPA1) signaling pathways, thereby regulating proliferation

potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor cell proliferation

STING) signaling pathway has been implicated in organ injuries and its activation inhibits endothelial proliferation

effectors recruited by GPCR-bound arrestins are Src family kinases, which regulate cellular growth and proliferation

knockout significantly suppressed malignant properties of breast cancer cells, such as inhibition of cell proliferation

February 2022 Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR

Ca2+]i), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation

signaling GPCR Binders, Drugs, and more Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation

or interference of ATG5 or ATG7 attenuated HBx-induced cell cycle acceleration and the subsequent proliferative lysyl oxidase; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MKI67: marker of proliferation

Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation

Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.

Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.

neurodegenerative diseases GPCRs in Neuroscience Primary cilia control oligodendrocyte precursor cell proliferation

GPCRs Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation

cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation

High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma