Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation However, the pathophysiological role of increased VIPR2 in the proliferation of breast cancer cells remains that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer cell lines, promoted cell proliferation Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation CCK8 and cell cloning were conducted to determine the proliferation ability of H1299 and Anip973 cells In vitro and in vivo experiments verified whether overexpression of RGS20 affect the proliferation and Further, RGS20 accelerated cell proliferation by increasing autophagy. Conclusion: Our findings indicate that RGS20 drives NSCLC cell proliferation by triggering autophagy

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation inducible factors, which sensitizes these receptors to NPY stimulation leading to enhanced migration and proliferation Here, we measured the effects of NPY1R and NPY5R antagonists in normoxia and hypoxia on migration, proliferation Antagonizing NPY1R and/or NPY5R in hypoxia compared to normoxia more greatly reduced MAPK signaling, cell proliferation

< GPCR News < GPCRs in Oncology and Immunology High expression of GPR50 promotes the proliferation, migration Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation Taken together, GPR50 may promote HCC progression via CCT6A-induced proliferation and PGK1-induced migration

KS-133, a newly developed VIPR2-selective antagonist peptide, attenuated VIP-induced cell proliferation through the cAMP/PKA/ERK and PI3K/AKT/GSK3β pathways, and mediates the G1/S transition to control cell proliferation Nakazawa , Souichi Yanamoto , Kotaro Tanimoto , Hitoshi Hashimoto , Yukio Ago Tags Cell cycle , Cell proliferation

The study explored the influence of GPR37 on tumor cell proliferation. prognosis. (2) It was demonstrated that GPR37 positively regulates NSCLC cell invasion, migration, and proliferation Conversely, we observed that GPR37 knockdown suppresses NSCLC cell invasion, migration, and proliferation

Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors , Therapeutic targeting , Tumor cell proliferation

We further examined PAR1 and PAR2 regulation of PCa cell proliferation and migration and found that absence of PAR1 promotes PC3 cell migration and suppresses cell proliferation, whereas PAR2 deficiency showed

Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing proliferation In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation

an agonist of GPR97, attenuated the psoriasis-like skin disease and restricted HaCaT cells abnormal proliferation this adhesion receptor may affect immune cell enrichment and function in skin and alter keratinocytes proliferation

and Immunology The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation

spatial and temporal requirements for GPCR activation of signaling pathways related to cell survival, proliferation

Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases Inhibition of S1P signaling abrogated the proliferative and anti-apoptotic effects of US28.

Blanco Redondo The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Proliferation Scholar X (Twitter) The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Proliferation

A positive correlation between GPR176 upregulation and the proliferation and poor overall survival of

The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well

epithelial cell-specific Adra2a knockout mice, we show that Enterococcus-derived tyramine suppresses ISC proliferation

Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell

to these tumor suppressor proteins may enhance immune surveillance, prevent carcinogenesis, counter proliferation

Functional annotation revealed their roles in critical cellular processes such as proliferation and GPCR

functionally, reexpression of circFKBP5 attenuated LPS-induced apoptosis, inflammation, and inhibition of proliferation

supports membrane interactions of proteins involved in various cellular processes, including migration, proliferation

Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and

Furthermore, proteases have an integral role in cell proliferation and growth because the proteolysis

Abstract "The long non-coding RNA (LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation

Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration

the four endmost C-terminal residues did not affect the inhibitory properties of CXCL10 on migration, proliferation

Willem Berend Post The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Proliferation