October 2022 "Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as diverse as receptor kinases, prostanoid receptors, purinergic receptors and ionic channels the evidence for PAR interactions with members of their own family, as well as with other types of receptors pathological relevance of these interactions, since this additional level of molecular cross-talk between receptors

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting attributed to the release of ATP via β2AR-Gs mediated activation, which subsequently transactivates purinergic receptors through Gq in intracellular stores [4]. Okashah, N., et al., Agonist-induced formation of unproductive receptor-G(12) complexes.  Stallaert, W., et al., Purinergic Receptor Transactivation by the β(2)-Adrenergic Receptor Increases

12 targeting effect of FDA approved purinergic receptor antagonist GPCRs in Cardiology, Endocrinology activated kidney fibroblasts expressing transcription factor 21 GPCRs in Neuroscience Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain GPCRs in Oncology Signaling Optical Approaches for Investigating Neuromodulation and G Protein-Coupled Receptor Signaling Protocol for identifying physiologically relevant binding proteins of G-protein-coupled receptors Reviews

Purinergic signaling, a form of extracellular paracrine signaling, relies on purine nucleotides. In the tumor microenvironment (TME), purinergic receptors such as ATP-gated ion channels P2X1-5 and G protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse associated receptors and enzymes." receptors , Purinergic signaling , Therapeutic potential , Tumor microenvironment (TME) Source Contribute

< GPCR News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive P2RY2 presents as the purinergic gene with the strongest association with hypoxia, the highest cancer Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to

adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled receptors (GPCRs) and purinergic signaling and now has four compounds in clinical trials.