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10 items found for "Qi Huang"
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
This question led Huang et al., 2022 to investigate the molecular basis involved in G protein-receptor pubmed.ncbi.nlm.nih.gov/35714614/ *Above information was taken from the original article published by Huang
- Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
., Huang, X. P., Macdonald, C. B., Mehrota, E., Grimes, P. R., ... & Manglik, A. (2024).
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
., Huang, X.-P., Macdonald, C. B., Mehrotra, E., Patrick Rockefeller Grimes, Zahm, A.
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- Overview of adhesion GPCRs self-activation
., Huang, Z., & He, Y. (2022).
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
., Huang, B., Wedegaertner, P. B., Conti, M., & von Zastrow, M. (2017).
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
used to predict subtype-selective ligands for dopamine receptors and adenosine receptors (He, Ben, Kuang , Wang & Kong, 2016; Kuang, Feng, Hu, Wang, He & Kong, 2016). 5.
- Regulators of G-protein signaling: essential players in GPCR signaling
Zhuang, Y., et al., Structural insights into the human D1 and D2 dopamine receptor signaling complexes
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and
