Considering this, we investigated the role of RGS20 as a potential prognostic marker in 28 different the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data, our analysis revealed that (a) RGS20 was strongly upregulated in tumor tissue compared with adjacent normal tissue of HCC patients; (b) RGS20 Taken together, we showed that RGS20 correlates with a few HCC-associated lincRNAs harboring oncogenic Our analysis further supports the putative function of RGS proteins, particularly RGS20, in cancer."

approach Opioid modulation of prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20

Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is Here we examined how the dual absence of RGS2 and 5 (Rgs2/5 dbKO) affects blood pressure and cardiac

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation its specific role and the mechanism through which RGS20 functions in NSCLC remain unclear. Further, RGS20 accelerated cell proliferation by increasing autophagy. RGS20 activation reduced YAP phosphorylation and facilitated its nuclear translocation. in RGS20-overexpressing cells.

< GPCR News < GPCRs in Oncology and Immunology In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors Regulator of G-protein signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed and selective RGS2 inhibitors. Differential scanning fluorimetry showed AJ-3 to bind RGS2 but not Gαq. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays.

We further focused on RGS14, RGS10, and RGS4. RGS14 exhibited seven significantly tolerant and seven significantly intolerant residues, RGS10 had six with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K, and tolerant RGS14-S127P and RGS10 In downstream cAMP measurement, tolerant RGS14-D137Y and RGS10-S64T and intolerant RGS10-K89M resulted