< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation its specific role and the mechanism through which RGS20 functions in NSCLC remain unclear. Further, RGS20 accelerated cell proliferation by increasing autophagy. RGS20 activation reduced YAP phosphorylation and facilitated its nuclear translocation. in RGS20-overexpressing cells.

< GPCR News < GPCRs in Oncology and Immunology In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors Regulator of G-protein signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed and selective RGS2 inhibitors. Differential scanning fluorimetry showed AJ-3 to bind RGS2 but not Gαq. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays.

We further focused on RGS14, RGS10, and RGS4. RGS14 exhibited seven significantly tolerant and seven significantly intolerant residues, RGS10 had six with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K, and tolerant RGS14-S127P and RGS10 In downstream cAMP measurement, tolerant RGS14-D137Y and RGS10-S64T and intolerant RGS10-K89M resulted

CXCR4, GPR34, LGR6, LPAR3, and RGS2 were significantly expressed in three OV datasets and enabled accurate