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Authors Ebru Ermis , Titli Nargis , Kierstin Webster , Sarah A Tersey , Ryan M Anderson , Raghavendra G Mirmira Tags G-protein coupled receptor (GPCR) , Macrophage , inflammation , metabolism , mouse ,

G. Aditya Kumar About Dr. G. Aditya Kumar Dr. G.

GPCR News < GPCRs in Oncology and Immunology Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer Published date April 25, 2023 Abstract " Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely However, it has become evident that heterotrimeric G-proteins can also be activated via GPCR-independent Tags G protein , GPCR , cancer , drug discovery .

About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human

< GPCR News < GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology Published date July 28, 2023 Abstract "G protein-coupled receptors (GPCRs), as the largest family of Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G

< GPCR News < GPCRs in Oncology and Immunology Intermediate-state-trapped mutants pinpoint G protein-coupled the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G transmembrane helix VI (TM6) and Helix8 that regulates cytoplasmic cavity opening as a "gatekeeper" for G Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets Published date September 27, 2024 Abstract "G-protein coupled receptors (GPCRs)

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors related to autoimmunity in In particular, the association of the disease with several types of anti-G protein-coupled receptor ( Authors Yoko Sunami, Keizo Sugaya, Kazushi Takahashi Tags G protein-coupled receptors , Autoimmunity

and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Three-Dimensional Missense Tolerance Ratio Analysis Published date January 1, 2023 Abstract Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling by acting as negative regulators of G proteins. activation, G α binding properties, and downstream cAMP levels.

< GPCR News < GPCRs in Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting Neutrophil Chemotaxis Published date April 11, 2023 Abstract " The current dogma is that chemoattractants G Tags G protein-coupled receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils

GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors Published date December 1, 2022 Abstract G Protein-coupled receptors (GPCRs

< GPCR News < GPCRs in Oncology and Immunology Signaling by Neutrophil G Protein-Coupled Receptors that Neutrophils, which express many receptors that are members of the large family of G protein-coupled receptors

GPCR News < GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Cell Mitophagy in Colorectal Cancer Published date March 11, 2023 Abstract " GPR176 belongs to the G Mechanistically, the G protein GNAS is recruited intracellularly to transduce and amplify extracellular

< GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor Published date April 29, 2024 Abstract "G protein-coupled Authors Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled

< GPCR News < GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor cells identify pleiotropic and cell type-specific functions Published date November 1, 2022 Abstract G-protein They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their Authors Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites studies have demonstrated that small-molecules from gut microbiota act as ligands for specific human G Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota

< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma Building on our previous finding that statins inhibit membrane association of G protein γ (Gγ) in a subtype-dependent findings indicate a plausible mechanism allowing for statins to differentially perturb heterotrimeric G

in Oncology and Immunology Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF mitoxantrone in untreated AML Published date September 12, 2023 Abstract "CC chemokine receptor-3 (hCCR3), a G Rodríguez-Arbolí , Megan Othus , Kelsey-Leigh A Garcia , Mary-Elizabeth M Percival , Ryan D Cassaday , Vivian G

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received Methods: Congruously regulated G protein-coupled receptor (GPCR)-related genes and differentially expressed Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis G protein signaling (RGS) protein family modulators play essential role within regulating downstream Our study focused on the expression patterns of RGS proteins in CRC, identifying Regulator of G protein

< GPCR News < GPCRs in Oncology and Immunology Identification of a G-protein coupled receptor-related G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency female mice Published date July 11, 2023 Abstract "OGR1 (Gpr68) and GPR4 (Gpr4) are proton-activated G Krudewig , Giovanni Pellegrini , Nicole Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled

Oncology and Immunology Prediction of survival and immunotherapy response by the combined classifier of G Wei , Tianyi Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G

< GPCR News < GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the carcinoma cells via inhibition of the c-Jun N-terminal kinase Published date November 13, 2024 Abstract "G protein-coupled receptor (GPCR) signaling regulates a wide range of pathophysiological cell functions via G

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled estrogen receptor (GPER)/GPR30 forms A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Published date January 10, 2024 Abstract "G protein-coupled receptor 30 (GPR30), also named G protein-coupled estrogen receptor (GPER), and the β1 -adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer

< GPCR News < GPCRs in Oncology and Immunology Activation of PI3K/Akt pathway by G protein-coupled receptor Among eukaryotes, the G protein-coupled receptor (GPCR) family stands as the largest group of membrane As a member of the GPCR family, G protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors