self-labelling enzyme protein tagging and interrogation of GPCR co-internalization Kilian Roßmann , Ramona Birke , Joshua Levitz , Ben Jones , Johannes Broichhagen Design of allosteric modulators that change

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Each of these receptors activates G protein-coupled inwardly rectifying potassium (GIRK) channels. have shown that co-activation using saturating concentrations of agonists results in occlusion of the GIRK The results indicate that a low tonic level of G βγ results in facilitation of GIRK current and a high The results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines Activation of either D2 or GABAB receptors also acutely desensitized the GIRK channel current induced

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