< GPCR News < GPCRs in Oncology and Immunology S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent This study investigated the sphingosine-1-phosphate (S1P) signaling-associated genes (SphK1 and S1PRs groups, we identified the differentially expressed genes and found a notable upregulation of SphK1, S1PR2 , and S1PR5 in IM-resistant CML. Authors Sikha Morang, Manisha Bisht, Vikas Upadhyay, Surabhi Thapliyal, Shailendra Handu Tags RNA-seq , S1PR

of the induction of CCN proteins by LPA, and by the related lipid mediator sphingosine-1-phosphate (S1P The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small Inducible CCNs can potentially play roles in downstream signal transduction events required for LPA and S1P-induced In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation In this way, an extracellular signal (LPA or S1P) can activate GPCR-mediated intracellular signaling

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable

Fifty-six GPCRs were upregulated in single Tcf21+ kidney fibroblasts, the most upregulated being Adgra2 and S1pr3 TCF21, ADGRA2, S1PR3 and ADORA2A/2B were each detectable in α-SMA+ interstitial cells in human kidneys