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autoantibodies targeting vasoregulatory and autonomic nervous system receptors Published date September 7, 2023 Methods: This monocentric, cross-sectional study included patients who suffered a mild to moderate SARS-CoV -2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID diagnosis according to the German S1 guideline or with no known history of SARS-CoV-2 infection (n = 70). and concentrations of evaluated autoantibodes were significantly higher in Long-COVID compared to the 2

tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Published date July 3, 2023 multiple functions of kinin receptors and KLKs, this review highlights their roles, even considering the SARS-CoV -2 effects. Pamela Ehrenfeld Tags KLKs , Kallikrein-related peptidases , Kinin receptors , Kinins , Lung cancer , SARS-CoV -2 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for

Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report Published date October 9, 2023 SARS-CoV-2 has now become the main trigger for ME/CFS.

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Breakfast 2 Date & Time Saturday, November 4th / 7:30 AM Previous Event Next Event Great Lakes Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Dinner 2 Date & Time Friday, November 3rd / 7:00 PM Previous Event Next Event Great Lakes GPCR Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd

Caron Tribute Part 2 About Marc Caron Dr. Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American Jacob Jacobson (2003) Dr. Stephane Laporte (1999) Dr. Stuart Maudsley (1997) Dr.

< GPCR News < GPCRs in Oncology and Immunology Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer Published date June Recently, a (methyl)lanthionine-stabilized, highly receptor-specific agonist of galanin subtype 2 (GAL2 Furthermore, a lanthionine-constrained agonist of angiotensin II type 2 (AT2) receptor inhibited PDX interacting with four tumor suppressor proteins, Src homology phosphatase 1, Src homology phosphatase 2,

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying Although leukotriene B4 receptor 2 (BLT2) has been characterized as a low affinity receptor to several

< GPCR News < GPCRs in Oncology and Immunology Neuroimmune interplay during type 2 inflammation: symptoms 2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators chronic, sustained inflammation and its related sensory pathologies in diseases associated with type 2 , FDA , FcεRIα , FeNO , Fractional exhaled nitric oxide , G-protein-coupled receptor , GPCR , Group 2 ) , PN , Protease activated receptor 2 , Provocative concentration causing a 20% drop in forced expiratory

Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Published date July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM ) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the production of type 2 cytokines.

Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling Published date September 1, 2023 Abstract "Neuropeptide FF (NPFF) belongs to the RFamide peptide Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2

< GPCR News < GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway Published date January 2, 2023 Abstract “ Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a class B G protein-coupled receptor with In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a

< GPCR News < GPCRs in Oncology and Immunology Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML Published date September 12, 2023 Abstract "CC

GPCRs in Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach Published date November 27 , 2023 Abstract "Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment

< GPCR News < GPCRs in Oncology and Immunology Blockade of vasoactive intestinal peptide receptor 2 ( signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells Published date March 1, 2024 Abstract "Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that

< GPCR News < GPCRs in Oncology and Immunology Expression pattern and clinical significance of beta 2- carcinoma: an emerging prognostic indicator and future therapeutic target Published date November 1, 2022 Abstract Purpose: Beta 2-Adrenergic Receptor (β2-AR) is significantly overexpressed in various types ± 1.93, p < 0.001; density 2.77 ± 1.17 vs. 1.28 ± 0.37, p < 0.001). In addition, β2-AR mRNA level was also upregulated in patients compared to the controls (2.36 ± 1.30

< GPCR News < GPCRs in Oncology and Immunology RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Published date November 28 , 2024 Abstract "The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature human T cells, revealing novel roles for the heterotrimeric G protein subunit Gβ1 and Casein Kinase 2

Immunology Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 However, stimulation of hM3Dq led to reduced IL-2 mRNA stability which correlated with an effect on the IL-2 3'UTR activity. This may explain the inhibitory impact on IL-2 production in hM3Dq/β1T cells. that activating the pAKT pathway is critical for IL-2 production in T cells."

in Oncology and Immunology Spliceosome mutations are associated with clinical response in a phase 1b/2 combination with decitabine in relapsed or refractory acute myeloid leukemia Published date November 1, 2023 In the phase 1b/2 trial, patients with SF mutations (SRSF2, SF3B1) had a higher CR/CRi rate (50%) compared

Authors & Affiliations "Ana Lilia Moreno Salinas (2), Arturo Mancini (1), Raida Jallouli (2), Richard Leduc (2) (1)Domain Therapeutics North America Inc, Montréal, Québec, Canada (2) Department of Pharmacology-Physiology Attendees Authors & Affiliations "Arturo Mancini (2), Samya Aouad (2,3), Herthana Kandasamy (2), Sandra Morrissette (2), Arhamatoulaye Maiga (4), Michel Bouvier (4), Richard Leduc (1), Laurent Sabbagh (2) Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada 2.

Retreat 2023 About Program Registration Logo Contest Committee Sponsors Registration Welcome to the Registration Portal for the 22nd GPCR Retreat taking place November 2-4, 2023 hosted at Fairmont Le Château Montebello Please note that the meeting can accommodate a maximum of 200 individuals. Please book your rooms by October 2, 2023 , to take advantage of the discounted rates. Abstract submission deadline: October 2, 2023 If you attend the GPCR Retreat, click here Great Lakes

L. (1) Arastoo, Mohammad Reza (1) Vejre, Phillip C. (1) Regmi, Rajesh (1) Perry-Hauser, Nicole A. (2) Bendix, Poul Martin (3) Javitch, Jonathan A. (2) Mathiasen, Signe (1) 1. Cechova Kristina3, Bandekar Sumit J.1, 2, Ethan Dintzner1, 2, Leon Katherine1, 2, Dutka Przemysław1, Siffer Gracie3, Kossiakoff Anthony A.1, Sando Richard 4, Vafabakhsh Reza3, Araç Demet1, 2 1. Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago; 2.

ABSTRACT SUBMISSION Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Submit your Abstract category (oral presentations) 2. Title: Capitalize each word, 20 words max, Bold 3. Speaker name indicated in bold and underlined Indicate abstract category on top left corner (up to 2 [ Registration extended until September 15th ] Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR Workshop 2024 and its preliminary program.

Welcoming Remarks 10/23/2024 10:00 AM Flash Presentations 10/23/2024 11:30 AM Coffee Break 10/23/2024 12:00 PM Session I 10/23/2024 01:00 PM Plenary Lecture 10/23/2024 2:00 PM Lunch 10/23/2024 3:00 PM Session Posters 10/24/2024 2:00 PM Lunch 10/24/2024 3:00 PM Session V 10/24/2024 4:30 PM Board Meeting 10/24 Lecture III 10/25/2024 1:00 PM Session VIII 10/25/2024 2:00 PM Lunch 10/25/2024 3:00 PM Session IX 10 /25/2024 4:30 PM Closing Remarks October 23, 2024 October 24, 2024 October 25, 2024 *Flash Presentations

Using RNAscope in situ hybridization (ISH) for GPR56, aquaporin 2 and NKCC2 (thick ascending limb, TAL Authors & Affiliations "Cechova Kristina (3), Bandekar Sumit J.(1, 2), Leon Katherine (1, 2), Dutka Przemysław (1, 4), Siffer Gracie (3), Kossiakoff Anthony A. (1), Vafabakhsh Reza (3), Araç Demet (1, 2) 1. Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; 2. Workshop Attendees Authors & Affiliations "Regmi, Rajesh (1), Perry-Hauser, Nicole A. (2), Javitch,

synthesizing labeled ligands, and her unique position that allows her to work with GPCR scientists on 2

TRAVELING TIPS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Register DO's It can include breakfasts. 2. Hotel Exe Suites Reforma 3. If your flight arrives at Terminal 2, there is a shuttle to Terminal 1. Typical costs are $8 USD one way ($2 USD / person carpooling with four people). Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event

Khaled Abdelrahman graduated in 2006 with a BSc in Pharmaceutical Sciences from Alexandria University (Egypt) followed by MSc in Pharmacology in the same university that was conferred in 2009. underlying altered cerebrovascular function and blood flow in type 2 diabetes. In 2015, He joined Dr. Providence College, she received the Walsh Grant Fellowship to develop novel methods of synthesizing 2