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August 2022 "Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics' potential antidepressant action." Read more at the source #DrGPCR #GPCR #IndustryNews

In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation Here, we find that protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing the N-terminal portion of β-catenin suppresses the ubiquitination of β-catenin, thereby promoting PAR-induced Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally

September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes." Read more at the source #DrGPCR #GPCR #IndustryNews

transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency Published date September 30, 2023 Abstract "Background: Spinal cord injury (SCI), which SCI leads to severe secondary immunosuppression, called SCI-induced immunodeficiency syndrome (SCI-IDS Tags Hypothalamo-pituitary-adrenal axis , Neuroendocrine immunomodulatory axis , Neuroinflammation , SCI-induced immunodeficiency syndrome , Transcriptome Source Contribute to the GPCR News Coming soon Become a Contributor

WHIM syndrome) and in the innate control of the life cycle of papillomavirus, which are commensal inhabiting discovery that CXCL12 is the ligand for the CXCR4 receptor and can therefore prevent infection by the Human Immunodeficiency

< GPCR News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced