Search Results

transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency Published date September 30, 2023 Abstract "Background: Spinal cord injury (SCI), which SCI leads to severe secondary immunosuppression, called SCI-induced immunodeficiency syndrome (SCI-IDS Tags Hypothalamo-pituitary-adrenal axis , Neuroendocrine immunomodulatory axis , Neuroinflammation , SCI-induced immunodeficiency syndrome , Transcriptome Source Contribute to the GPCR News Coming soon Become a Contributor

< GPCR News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced

WHIM syndrome) and in the innate control of the life cycle of papillomavirus, which are commensal inhabiting discovery that CXCL12 is the ligand for the CXCR4 receptor and can therefore prevent infection by the Human Immunodeficiency

< GPCR News < GPCRs in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced The addition of lysophosphatidic acid (LPA) further hindered CXCL12-induced Gαi/o recruitment to CXCR4 LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA1-selective antagonists enhanced CXCL12-induced Gαi/o signaling and cell migration in the parental

< GPCR News < GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid differentiation summary, this study demonstrated that activation of orphan GPR132 represents a potential strategy for inducing

Immunology GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease model to study EBV-induced

GPCR News < GPCRs in Oncology and Immunology Metallo-protease Peptidase M84 from Bacillusaltitudinis induces This metallo-protease had no discernible impact on normal cell survival, but it specifically induced We observed that Peptidase M84 induced PAR-1 overexpression along with activating its downstream signaling findings suggested that Peptidase M84 triggered PAR-1-mediated oxidative stress to act as an apoptosis inducer

< GPCR News < GPCRs in Oncology and Immunology GPR97 depletion aggravates imiquimod-induced psoriasis ) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity as well as induce hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected in imiquimod (IMQ)-induced Additional investigations indicated that beclomethasone dipropionate (BDP), an agonist of GPR97, attenuated

GPCR News < GPCRs in Oncology and Immunology Stimulation of ectopically expressed muscarinic receptors induces pathways in primary T cells Published date June 12, 2023 Abstract "T cell antigen receptor stimulation induces muscarinic receptor could bypass tyrosine kinases to activate the phosphatidylinositol pathway and induce Clozapine treatment induced high IFN-γ, CD69, and CD25 expression, but surprisingly did not induce substantial Stimulation of muscarinic receptors induced strong nuclear translocation of NFAT and NFκB and activated

downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced mechanism of G protein-coupled receptor class C group 5 member A (GPRC5A) on lipopolysaccharide (LPS)-induced The mRNA and protein levels of GPRC5A in GFs under 1 mg/L LPS-induced GFs inflammatory state were evaluated RT-qPCR was used to detect the gene expression levels of the inflammatory cytokines in GFs induced by group (0.39±0.03, 1.06±0.16) also inhibited the increase of GPRC5A at both gene and protein levels induced

News < GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced We have previously reported that transforming growth factor-α (TGF-α) induces the migration of human This study aims to determine whether Gβγ subunits regulate the TGF-α-induced migration of HCC HuH7 cells Gallein significantly reduced the TGF-α-induced cell migration. These results strongly suggest that Gβγ subunits act as positive regulators in TGF-α-induced migration

Immunology Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced Most importantly, we investigated whether GPR37 affects cisplatin-induced drug resistance in NSCLC.

brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced

date September 1, 2023 Abstract "CCN1 and CCN2 are matricellular proteins that are transcriptionally induced Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small Inducible CCNs can potentially play roles in downstream signal transduction events required for LPA and S1P-induced responses.

Restoration of synaptic connections induced by low-dose ketamine has been found associated with the sustained synapses in prefrontal cortical neurons of chronically stressed animals and their behavioral remission induced In vivo intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient

by binding to numerous GPCRs, controlling their steady state trafficking and sometimes their agonist-induced We show that Norbin mediates the agonist-induced internalisation of C5aR1 through a β-arrestin-dependent does not control the constitutive internalisation of C5aR1 and CXCR4, nor does it affect the agonist-induced trafficking generally, by identifying its importance in β-arrestin recruitment, β-arrestin dependent agonist-induced CXCR4 , G protein-coupled receptor (GPCR) , GPCR trafficking , Ncdn , Neurochondrin , P-Rex1 , agonist-induced

SRP gene expression has been also demonstrated to be enhanced by GBP, indicating that both cytokines Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor GBP2 derived enhancement of GBP1 expression was not observed in the presence of GBP1, indicating that GBP2-induced enhancement of GBP1 expression was not observed in Mthl10 knockdown cells. control immune responses as well as their own expression levels through a hierarchical cytokine network, indicating

In The Closest Relatives Of Animals Alain Garcia De Las Bayonas Critical role for CD97/ADGRE5 in the induction Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing Additionally, the bacterium Vibrio fischeri also induces mating in S. rosetta cultures, suggesting that We found that the knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the Alain Garcia De Las Bayonas on the web King Lab Critical role for CD97/ADGRE5 in the induction of allergic

Previous studies have indicated that GPR50 could protect against breast cancer development and decrease Taken together, GPR50 may promote HCC progression via CCT6A-induced proliferation and PGK1-induced migration

mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre+/-;Gnaqfl/fl;Gna11-/-) and inducible Tamoxifen-induced mesenchymal Gαq/11 gene deletion in adult mice resulted in emphysema associated with Cyclical mechanical stretch-induced TGFβ activation required Gαq/11 signalling and serine protease activity These data highlight a previously undescribed mechanism of cyclical stretch-induced Gαq/11-dependent

GBM cells using a novel highly specific small molecule inhibitor of GPR68 named Ogremorphin (OGM) to induce Our major indication, ferroptosis, was then confirmed by western blotting and qRT-PCR of reporter genes We use U87 and U138 glioblastoma cell lines to show how selective induction of ferroptosis occurs in Conclusion: These results indicate GPR68 emerges as a critical sensor for an autocrine pro-tumorigenic These findings provide a promising therapeutic approach to selectively induce ferroptosis in glioblastoma

In vitro results suggest that several of the novel small-molecule compounds could inhibit GHRH-induced Preliminary analysis of the specificity/selectivity of one of the most effective hit compounds indicated therefore report the first nonpeptide antagonists of GHRHR and propose a structural basis for inhibition induced

In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing a >2-fold increase in mRNA expression after fibrosis induction. stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced

self-renewal in mice Published date December 8, 2023 Abstract " Background: Acute respiratory distress syndrome In an in vivo study, the effects of RGS6 knockout were studied in a mouse model of ALI induced by lipopolysaccharide

CircFKBP5 expression was decreased in hDPSCs and, functionally, reexpression of circFKBP5 attenuated LPS-induced LPS induced miR-708-5p expression in hDPSCs, and knockdown of miR-708-5p protected against LPS-evoked Conclusions: CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation

Here, we show that a combination of insulin and the GPCR agonist neurotensin induced rapid activation results also demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown of YES and Src induces Dasatinib-induced ERK activation was completely abolished by exposure to the FDA-approved MEK inhibitor

increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Due to the urgency of finding therapies for post-COVID-Syndrome (PCS), we report here the interim results Markus Tölle , Carmen Scheibenbogen Tags GPCR-antibodies , Myalgic Encephalomyelitis/Chronic Fatigue Syndrome , SF-36 , autoantibodies , immunoadsorption , long COVID , physical function , post-COVID syndrome Source

Immunology G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome Published date June 20, 2024 Abstract "Postural orthostatic tachycardia syndrome (POTS) is characterized