Search Results
28 items found for "Sandra L Silberman"
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
Authors Peter J P Croucher , Maya Ridinger , Pamela S Becker , Tara L Lin , Sandra L Silberman , Eunice
- Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease
Contest Committee Sponsors GPCR Retreat Program < Back to schedule Cannabinoid compounds to augment L-DOPA
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
After exposure to 0.01-10 μg/L CPPDQ, obvious body accumulation of CPDDQ was detected. Meanwhile, exposure to CPPDQ (0.01-10 μg/L) decreased head thrash, body bend, and forward turn, and increased Nevertheless, only exposure to 10 μg/L CPPDQ induced neurodegeneration in GABAergic system. Exposure to CPPDQ (0.01-10 μg/L) further decreased expressions of daf-7 encoding TGF-β ligand, jnk-1 Additionally, among examined G protein-coupled receptor (GPCR) genes, exposure to CPPDQ (0.01-10 μg/L)
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
GFs were isolated with enzymic digestion and transfected with 30, 50 and 80 μmol/L small interfering The mRNA and protein levels of GPRC5A in GFs under 1 mg/L LPS-induced GFs inflammatory state were evaluated The 50 μmol/L group displayed the most significant decrease in GPRC5A expression (31.16±3.29) compared Authors Y H Hu , L L Shang , S H Ge Source Contribute to the GPCR News Coming soon Become a Contributor
- Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML
Mary-Elizabeth M Percival , Ryan D Cassaday , Vivian G Oehler , Pamela S Becker , Jacob S Appelbaum , Janis L Abkowitz , Johnnie J Orozco , Siobán B Keel , Paul C Hendrie , Bart L Scott , M Cristina Ghiuzeli , Elihu
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
xenografts of colorectal carcinoma in mice Published date February 1, 2023 Abstract " LP2 is a 4, 7 D, L warrant further evaluation of LP2's inhibitory potential of colorectal cancer. " Authors P Namsolleck , L
- Ep 107 with Dr. Roger Sunahara
forms, specifically the short and long forms of the stimulatory G protein, Galpha-s(s) and Galpha-s(l) We demonstrated that Galpha-s(l), but not Galpha-s(s), regulates extracellularly regulated kinases (ERK We speculate that these aberrations in Galpha-s(l), specifically, may be involved in other pathologies
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
., Pyrrosia calvata (Baker) Ching, Plantago asiatica L. and stigma of Zea mays L.
- Ep 105 with Annabelle Milner
In particular, she is looking at L- and D-lactate-activated HCAR1 signaling.
- Emerging GPCR targets for AUD: Insights from preclinical studies
Authors Roberta Goncalves Anversa, Maiya L Barron, Leigh C Walker, Andrew J Lawrence Source Contribute
- Dopamine-Mediated Motor Recovery after Ischemic Stroke
hope our research will aid in the development of new therapeutic interventions for the alleviation of L-DOPA-induced
- Ep 103 with Dr Kathleen Caron
Caron, Ph.D. is the Frederik L.
- From odor to oncology: non-canonical odorant receptors in cancer
Authors Sung Jin Park , Paul L Greer , Namgyu Lee Source Contribute to the GPCR News Coming soon Become
- CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes
Authors Kavita Rawat , Anita Tewari , Xin Li , Arlind B Mara , William T King , Sophie L Gibbings , Chinaza
- Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
Papadourakis, Konstantinos Tsianakas, Robert P Millar, Ross C Anderson, Georgios A Spyroulias, Claire L
- Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
Authors Guangrong Qin, Jin Dai, Sylvia Chien, Timothy J Martins, Brenda Loera, Quy H Nguyen, Melanie L
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Caron, Ph.D. is the Frederik L.
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
homeostasis. " Authors Amanda T Goodwin , Alison E John , Chitra Joseph , Anthony Habgood , Amanda L
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
Kaur , Veera Ganesh Yerra , Sri Nagarjun Batchu , Duc Tin Tran , Md Golam Kabir , Youan Liu , Suzanne L
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
Authors Julia Tutzauer , D Stephen Serafin , Tobias Schmidt , Björn Olde , Kathleen M Caron , L M Fredrik
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
Authors Mithila Tennakoon , Waruna Thotamune , John L Payton , Ajith Karunarathne Tags HMG-CoA reductase
- Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
Tasmin Farzana, Colin Rueda, David J Chung, Heather J Landau, Oscar B Lahoud, Michael Scordo, Gunjan L
- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
24 Attendees Authors & Affiliations "Arturo Mancini (2), Samya Aouad (2,3), Herthana Kandasamy (2), Sandra
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
available for AGPCR 24 Workshop Attendees Authors & Affiliations "Rosell, Júlia (1) Holmkvist, Jesper L. Bernadyn, Mariane Nascimento, Xinyi Lu, Pauline L. Pan, Michael Holinstat and Gregory G.
- GPCR Retreat 2023 - Part I
Caron, Ph.D. is the Frederik L.
- Classified News | Dr. GPCR Ecosystem
profile Read More December 1, 2024 Intranasal delivery of liposome encapsulated flavonoids ameliorates l-DOPA
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Authors & Affiliations "Vukadin L, Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong K, Murphy JM, Harvey CA, Dunlap S, Gehrs L, Lee H, Kim HG, Sah JP, Lee SN, Stanford D, Barrington RA