In ACKR3, the presence of a tyrosine at position 6.40 plays a role in its constitutive activity (Yen, Schafer et al. 2022) which is also supported by mutagenesis studies (Han, Tachado et al. 2012, Yen,

dynamics ( e.g FLAsH biosensor [11]), cAMP production (e.g CAMYEL assay [12]) , and ERK activity (e.g YEN

of cytosolic effector proteins: the G proteins after which GPCRs are named, and arrestins which both shut

modulating ligand binding, as well as G-protein coupling or interaction with other signaling molecules (Sohy represent the typical protein-protein interactions which are difficult to modulate using small molecules (Sohy