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130 items found for "Shunda Du"
- Michel Bouvier appointed Knight of the Ordre national du Québec
of the Faculty of Medicine of the Université de Montréal, is appointed Knight of the Ordre national du
- Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias Here we examined how the dual absence of RGS2 and 5 (Rgs2/5 dbKO) affects blood pressure and cardiac
- Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent The purpose of this study was to evaluate the role of dual transactivation of EGF and TGF-β receptors of G protein-coupled receptor (GPCR) signaling, the functions of ROCK and PLC were investigated in dual
- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during In this study, the expression and signaling of β2-ADR in B cells during collagen-induced arthritis (CIA without stimulation of β2-ADR agonist terbutaline by flow cytometry. β2-ADR-expressing B cells increase during The change of β2-ADR expression and signaling during sustained inflammation might be an integral part
- AcroScreen co-founder Margaux Duchamp has been selected as a 30 under 30 Europe Forbes ranking 2022
May 2022 "We are thrilled to announce that our co-founder Margaux Duchamp has been selected as a 30 under
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein synthesis, and subsequent cardiomyocyte growth. In this article, we describe the signal transduction elements that regulate PLC gene expression. The discussion is focused on the norepinephrine- α1-adrenoceptor signaling pathway and downstream signaling processes that mediate an upregulation of PLC isozyme gene expression. Evidence is also indicated to demonstrate that PLC activities self-regulate the expression of PLC isozymes with the suggestion that PLC activities may be part of a coordinated signaling process for the perpetuation of cardiac hypertrophy. Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted for the mitigation of cardiac hypertrophy." Read more at the source #DrGPCR #GPCR #IndustryNews
- Therapeutic validation of an orphan G protein‐coupled receptor
., 2015, Du Toit et al., 2018).
- 🤯Mind-blowing GPCR Scoops! Discover the Latest Breakthroughs! ⦿ Nov 18 - 24, 2024
Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G Salmerón , Paul A Insel PGxDB: an interactive web-platform for pharmacogenomics research Trinh Trung Duong repurposing to prevent and treat murine colitis and sepsis GPCRs in Oncology and Immunology Pancreatic ductal
- Reflections on My PhD Journey: Lessons Learned
You Go The PhD journey is often compared to a rollercoaster, and I found this to be especially true during
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors Dual
- Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
conservation of these residues can lead to the development of drugs that are less likely to lose effectiveness due Deep mutational scanning, for instance, is gaining popularity as a strategy due to its ability to comprehensively
- AlphaFold’s Breakthrough in GPCR Research: Revolutionizing Discovery, Yet Awaiting Experimental Proof
structural templates, allowing it to predict structures for GPCRs that were previously difficult to model due models revealed distinct ligand-binding site shapes, enabling the prioritization of different chemotypes during
- 📢 Early Bird Registration Ends Tomorrow! | Sep 16 - 22, 2024
Google DeepMind And Isomorphic Labs Are Making Rapid Progress In Biology And Drug Discovery GLP-1/FGF21 dual
- Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
effectively leveraged in drug discovery, as demonstrated by the development of tirzepatide, a GLP-1R/GIPR dual Willard, F.S., et al., Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
peripheral metabolism and systemic energy homeostasis Eiken syndrome with parathyroid hormone resistance due
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
During this process, APEX2 can label proteins in the vicinity, allowing the capture of a snapshot of
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Furthermore, probing species- or subtype-selectivity introduces complexities due to the differing contexts
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
Dates: September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic Dates: October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays
- Do You Believe AI Could Accelerate Drug Discovery?
However, the impact on structure-based ligand discovery remained uncertain due to the necessity for accurately Science https://doi.org/10.1126/science.adn6354 (2024) Abramson, J., Adler, J., Dunger, J. et al.
- Canonical chemokine receptors as scavenging “decoys”
The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging
- Adhesion GPCR Consortium Newsletter - May 2024
The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their people should absolutely experience: The Day of the Dead celebrations: This happens over the weekend during
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
This emphasis may have caused other signaling pathways to be overlooked due to a need for adequate assay This dual role opens new possibilities for more complex and nuanced cellular responses.
- 📰 GPCR Weekly News, May 13 to 19, 2024
structures guide prospective ligand discovery Industry News Roche reports positive Phase Ib results for its dual
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
However, these conventional assays often provide limited information on intermediate signaling events due
- 📰 GPCR Weekly News, April 22 to 28, 2024
increases the risk of obesity GPCR Activation and Signaling Variable CGRP family peptide signaling durations
- From DNA day to GPCR genomics
beta-adrenergic receptor (βAR), the first GPCR to be identified by Robert Lefkowitz and colleagues during This variation is due to factors such as alternative splicing, gene duplications, and variability in crystallography and cryo-electron microscopy, have allowed us to understand the structural dynamics during For example, we know that transmembrane helices move during receptor activation and that the DRY motif Additionally, there have been recent discoveries of the conformational changes that occur during G-protein
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
Those include the risk of unintended off-target effects, limited selectivity due to closely related receptor This variability in drug effects is due to different ligands inducing unique GPCR conformations that
- 📰 GPCR Weekly News, February 19 to 25, 2024
receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegan Species-Specific Duplicated