of the Faculty of Medicine of the Université de Montréal , is appointed Knight of the Ordre national du

October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte Here we examined how the dual absence of RGS2 and 5 (Rgs2/5 dbKO) affects blood pressure and cardiac

September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during In this study, the expression and signaling of β2-ADR in B cells during collagen-induced arthritis (CIA without stimulation of β2-ADR agonist terbutaline by flow cytometry. β2-ADR-expressing B cells increase during The change of β2-ADR expression and signaling during sustained inflammation might be an integral part

September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent The purpose of this study was to evaluate the role of dual transactivation of EGF and TGF-β receptors of G protein-coupled receptor (GPCR) signaling, the functions of ROCK and PLC were investigated in dual

May 2022 "We are thrilled to announce that our co-founder Margaux Duchamp has been selected as a 30

September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein synthesis, and subsequent cardiomyocyte growth. In this article, we describe the signal transduction elements that regulate PLC gene expression. The discussion is focused on the norepinephrine- α1-adrenoceptor signaling pathway and downstream signaling processes that mediate an upregulation of PLC isozyme gene expression. Evidence is also indicated to demonstrate that PLC activities self-regulate the expression of PLC isozymes with the suggestion that PLC activities may be part of a coordinated signaling process for the perpetuation of cardiac hypertrophy. Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted for the mitigation of cardiac hypertrophy." Read more at the source #DrGPCR #GPCR #IndustryNews

., 2015, Du Toit et al., 2018).

Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors Dual

conservation of these residues can lead to the development of drugs that are less likely to lose effectiveness due Deep mutational scanning, for instance, is gaining popularity as a strategy due to its ability to comprehensively

Google DeepMind And Isomorphic Labs Are Making Rapid Progress In Biology And Drug Discovery GLP-1/FGF21 dual

effectively leveraged in drug discovery, as demonstrated by the development of tirzepatide, a GLP-1R/GIPR dual Willard, F.S., et al., Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.  

peripheral metabolism and systemic energy homeostasis Eiken syndrome with parathyroid hormone resistance due

During this process, APEX2 can label proteins in the vicinity, allowing the capture of a snapshot of

Furthermore, probing species- or subtype-selectivity introduces complexities due to the differing contexts

Dates:  September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic Dates:  October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays

However, the impact on structure-based ligand discovery remained uncertain due to the necessity for accurately Science https://doi.org/10.1126/science.adn6354 (2024) Abramson, J., Adler, J., Dunger, J. et al.

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging

The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their people should absolutely experience: The Day of the Dead celebrations: This happens over the weekend during

This emphasis may have caused other signaling pathways to be overlooked due to a need for adequate assay This dual role opens new possibilities for more complex and nuanced cellular responses.

structures guide prospective ligand discovery Industry News Roche reports positive Phase Ib results for its dual

However, these conventional assays often provide limited information on intermediate signaling events due

increases the risk of obesity GPCR Activation and Signaling Variable CGRP family peptide signaling durations

beta-adrenergic receptor (βAR), the first GPCR to be identified by Robert Lefkowitz and colleagues during This variation is due to factors such as alternative splicing, gene duplications, and variability in crystallography and cryo-electron microscopy, have allowed us to understand the structural dynamics during For example, we know that transmembrane helices move during receptor activation and that the DRY motif Additionally, there have been recent discoveries of the conformational changes that occur during G-protein

Those include the risk of unintended off-target effects, limited selectivity due to closely related receptor This variability in drug effects is due to different ligands inducing unique GPCR conformations that

receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegan Species-Specific Duplicated

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric strength of an allosteric effect as agonist's efficacy GPCR Binders, Drugs, and more Nanobody-Mediated Dualsteric GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during

Due to popular demand, we have opened additional spots. If you'd like to join colleagues and Dr. Classified GPCR News from January 15th to 21st, 2024 Adhesion GPCRs The adhesion GPCR GPR116/ADGRF5 has a dual

families in gastropods Unraveling the G protein-coupled receptor superfamily in aphids: Contractions and duplications