ability to perform, understand, and communicate GPCR pharmacology data analysis to a high level, as well

Recent advancements in transcriptomic profiling have provided new insights into the expression patterns of GPCRs across different cell types. The study reports that human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 semi-quantitative multiplex PCR method, which allowed for the detection of both abundant and rare GPCR transcripts , including B cells, CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and dendritic cells.

Using multiplexed single-cell transcriptomics, we analyze human neural precursor cells (hNPCs) from sporadic

into studies focused on obtaining detailed molecular information in the intracellular context ("in-cell ") or those focused on characterizing molecules or events at the cell surface ("on-cell"). In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution with cell surface membrane proteins such as G-protein coupled receptors (GPCRs) and receptor tyrosine We also provide a brief survey of the applicability of on-cell NMR approaches to other classes of cell

NKTCL), a representative disease model to study EBV-induced lymphomagenesis, incorporating genomic, transcriptomic Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient cell killing in NKTCL organoid. Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment , Multi-omics , Single-cell transcriptome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News

GPCRs in Oncology and Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies Published date October 23, 2023 Abstract Glioblastoma multiforme (GBM) conducted to explore the role of GNAI3 in co-expressed genes and associated signaling pathways using a transcript regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell A single-cell analysis was used to assess GNAI3 expression in GBM.

< GPCR News < GPCRs in Oncology and Immunology Single cell G-protein coupled receptor profiling of Transcription Experimental approach: RNA sequencing and single cell qRT-PCR were performed on mouse kidneys after unilateral Key results: Transcription factor 21 (Tcf21)+ cells that expressed 2 or 3 of Postn, Acta2 and Pdgfra Tcf21+ α-smooth muscle actin (α-SMA)+ interstitial cells accumulated in the kidneys of mice with UUO Fifty-six GPCRs were upregulated in single Tcf21+ kidney fibroblasts, the most upregulated being Adgra2