Seo , Ji Yeong Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki

Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline OGR1 deficiency, however, increases crystal deposition leading to impaired kidney function. Thus, OGR1 may be important to limit kidney crystal deposition, which might subsequently be relevant for the pathophysiology of oxalate kidney stones or other crystallopathies."

< GPCR News < GPCRs in Oncology and Immunology Minireview: functional roles of tissue kallikrein, kinins suffering from lung cancer is to target surface receptors overexpressed on tumor cells, such as GPCR-family kinin Considering the multiple functions of kinin receptors and KLKs, this review highlights their roles, even Villarroel-Espindola , Carlos D Figueroa , Pamela Ehrenfeld Tags KLKs , Kallikrein-related peptidases , Kinin receptors , Kinins , Lung cancer , SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become

< GPCR News < GPCRs in Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK combination of insulin and the GPCR agonist neurotensin induced rapid activation of Src family of tyrosine kinases

Immunology Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts Correlative histology was performed in human kidney tissue. Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .

News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced kidney

< GPCR News < GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing GPCR kinases (GRKs) can regulate GPCR activation. and antimicrobial functions (cytoskeletal reorganization, chemotaxis (CTX), phagocytosis, bacterial killing Actin polymerization, CTX, bacterial phagocytosis and killing were also rescued therefore by the HDAC Banner-Goodspeed , Krystal R Capers , Seong-Gyu Ko , Leo E Otterbein , Kiyoshi Itagaki , Carl J Hauser

receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells C-terminal tails through which they interact in the plasma membrane with membrane-associated guanylate kinase (MAGUK) scaffold proteins, and in turn protein kinase A anchoring protein (AKAP) 5.

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

Authors Brian Kim , Marc E Rothenberg , Xin Sun , Claus Bachert , David Artis , Raza Zaheer , Yamo Deniz , Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase G-protein-coupled receptor 3 , Mas-related family of G-protein-coupled receptors , Mitogen-activated protein kinase

Authors Mor Oron-Herman , David Kirmayer , Amelie Lupp , Stefan Schulz , Genady Kostenich , Michel Afargan

Authors Eri Oguro-Igashira, Mari Murakami, Ryota Mori, Ryuichi Kuwahara, Takako Kihara, Masaharu Kohara Daisuke Motooka, Daisuke Okuzaki, Mitsuru Arase, Hironobu Toyota, Siyun Peng, Takayuki Ogino, Yasuji Kitabatake , Eiichi Morii, Seiichi Hirota, Hiroki Ikeuchi, Eiji Umemoto, Atsushi Kumanogoh, Kiyoshi Takeda Tags

CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer calcium mobilization assays and through quantification of phosphorylated extracellular signal-regulated kinase -1/2 (ERK1/2) and protein kinase B/Akt.

Overexpressed VIPR2 caused increases in the levels of cAMP and phosphorylated extracellular signal-regulated kinase Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation

Jinqiancao granules are a traditional Chinese medicine used to treat kidney stones and this medicine

Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor.

chemoattractants G protein-coupled receptors (GPCRs) activate β phospholipase C (PLCβ) while receptor tyrosine kinases

Mitochondrial Morphology in Axons Joseph Duman Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase in Axons Joseph Duman Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Tolias, Kimberley Of The Psychiatric Risk Kinase TNIK Simeon R. I then moved to King's College London, where my interest and passion for kinases in brain health and I also work on multiple other kinases in our laboratory implicated in various neurodevelopmental and

Authors Purbasha Bhattacharya , Umesh Kumar Dhawan , Mohammed Tayab Hussain , Praveen Singh , Karran Kiran

molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors by protein kinase

He shared his experience working on a project involving receptor kinases and collaborating with other

Authors Sharmistha Banerjee , Taeyeop Park , Yoo Sun Kim , Hee-Yong Kim Tags Adenylyl cyclase , Cytokines

the Yes-associated protein (YAP), and its association with cell migration was further confirmed by kinase

The role of GPR56 in the kidneys has been understudied. A recent study demonstrated that GPR56 in the glomerular endothelial cells promoted diabetic kidney disease physiology, I systematically characterized the function of sodium/hydrogen exchanger 3 in the intestine and kidneys Bill Huang Abstract Only available for AGPCR 24 Workshop Attendees Authors & Affiliations "Hee-Yong Kim consequences associated with the GPR110 receptor. " Authors & Affiliations "Joel Toro, Bill Huang, Hee-Yong Kim

Authors Elisa Stein , Cornelia Heindrich , Kirsten Wittke , Claudia Kedor , Laura Kim , Helma Freitag

Rezwan Parag Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney K, Murphy JM, Harvey CA, Dunlap S, Gehrs L, Lee H, Kim HG, Sah JP, Lee SN, Stanford D, Barrington RA These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney. Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney.

expression of angiogenesis markers, and G-protein-coupled receptor (GPCR)-mitogen-activated protein kinase

University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases