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Using time-resolved cryo-electron microscopy (cryo-EM) and variability analysis to monitor the transitions high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by targeting specific Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024).

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways while a new estrogen receptor, namely G protein-coupled estrogen receptor (GPER), is demonstrated to mediate At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

August 2022 "A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a "Breakthrough Therapy" for treatment-resistant depression, a new path has been forged for the conveyance of psychedelics to the clinic. Essential to the further development of such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular level. Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic mechanisms." Read more at the source #DrGPCR #GPCR #IndustryNews

His main area of research focuses on the structural and pharmacological bases for hormone-mediated activation These approaches were invaluable to resolve the crystal structure of the beta2-adrenergic receptor (beta2AR was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models for agonist-mediated Some of these studies resolved a major question regarding the signaling differences in G protein splice We speculate that these aberrations in Galpha-s(l), specifically, may be involved in other pathologies

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For instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions (Nature communications, 2015, 2021, 2022 We identified that arrestin can mediated AT1R/TRPC3 or M3R/TRPC3 coupling by forming a complex of AT1R