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13 items found for "Splicing"
- Adhesion GPCR Consortium Newsletter - May 2024
that the field will have to face in the next 10 years is deciphering the physiological relevance of splice-dependent Alternative splicing events account for hundreds, if not thousands, of potentially divergent isoforms The distribution, functionality, and structure of the multiple splice isoforms that adhesion GPCRs possess aGPCR works but might also provide a guide to how pharmacological approaches will be developed, i.e., splice , for understanding tissue distribution of alternatively spliced genes.
- TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
gastrointestinal cells, we show that these isoforms emerge from distinct promoter usage and alternative splicing
- Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
Although mature forms of PTHrP in the body consist of splice variants of 139, 141, and 173 amino acids
- 📰 GPCR Weekly News, July 17 to July 23, 2023
A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants,
- From DNA day to GPCR genomics
This variation is due to factors such as alternative splicing, gene duplications, and variability in
- VAMP2: a crucial player in the delivery of MOR to the synapse
These data are fascinating because in the case of MOR, which is a receptor with several splicing variants
- 📰 GPCR Weekly News, May 27 to June 2, 2024
target for CNS disorders - an in silico approach GRN knockdown regulates the expression and alternative splicing
- 📰 GPCR Weekly News, February 12 to 18, 2024
cortical gene expression after antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing
- Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
pharmacological inhibition of its upstream regulators, Gβγ or Gq, ex vivo in periaqueductal gray (PAG) slices
- Co-activation of GPCRs facilitate GIRK-dependent current
Recordings in brain slices have shown that co-activation using saturating concentrations of agonists
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
In brainstem slices, intracellular constitutively active ROCK2 (aROCK2) led to H1152-sensitive HMN hyper-excitability
- 📰 GPCR Weekly News, October 30 to November 4, 2023
Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Spliceosome mutations are associated