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September 2022 "Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients. Alterations in gene expression appear in pathways related to primary cilia (PC). Accordingly, in these hiPSC-derived hNPCs and neurons, we observe a shortening of PC. Additionally, we detect a shortening of PC in PINK1 -deficient human cellular and mouse models of familial PD. Furthermore, in sPD models, the shortening of PC is accompanied by increased Sonic Hedgehog (SHH) signal transduction. Inhibition of this pathway rescues the alterations in PC morphology and mitochondrial dysfunction. Thus, increased SHH activity due to ciliary dysfunction may be required for the development of pathoetiological phenotypes observed in sPD like mitochondrial dysfunction. Inhibiting overactive SHH signaling may be a potential neuroprotective therapy for sPD." Read more at the source #DrGPCR #GPCR #IndustryNews

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August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory Background: Inflammatory microenvironment promotes odontoblastic differentiation in human dental pulp stem

His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations

will have a $5 attendance fee/ talk You can get full access to all the talks for $100 For Speakers Step 1: Let us know that you'd like to present your work by filling out this short form here Step 2: Prepare your video abstract and your presentation (pre-recorded or live)* Step 3: Click here to send us your

Organoid culture was used to assess the stemness and self-renewal capacity of alveolar epithelial type plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung stem