September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein

October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and Currently, a controversy exists as to whether cGAS/STING activation exacerbates inflammation and tissue This study unveiled a new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and

We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1. Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1 significantly reduced the uptake, which was accompanied by the nullification of the promoting effect of F-Hst1 We further showed the intracellular trafficking and targeting process of F-Hst1, in which early endosome

significant decrease in GPRC5A expression (31.16±3.29) compared with that of the NC group (100.00±4.88) (F= inhibited the increase of GPRC5A at both gene and protein levels induced by LPS (1.30±0.10, 1.43±0.03) (F= 208.38, P<0.001; F=42.04, P<0.001).

Ben’s research focuses on Smoothened and other class F GPCRs which play essential roles in embryonic

Otávio Cabral-Marques , Joana P Bernardes , Neha Mishra , Thomas Bahmer , Jeanette Franzenburg , Bimba F