Search Results
65 items found for "Systemic treatment"
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
< GPCR News < GPCRs in Oncology and Immunology Exploration of prognostic and treatment markers in hepatocellular elucidated, and GPCR-related genes were employed for building a risk-score model for the prognosis and treatment prediction model was constructed by only GPCR-related genes, which are all potential targets for HCC treatment , Baoluhe Zhang , Xiaokun Chen , Xiao Liu , Xueshuai Wan , Shunda Du Tags GPCR ; HCC ; Prognosis ; Systemic treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling Overall, this work highlights the power of mechanism-based computational systems biology as a discovery
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System conditioning, whereby metabolites such as butyrate affect immune cells as they pass through the portal venous system
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
News < GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment development of antibodies against CCR6 that could be a promising alternative to small molecules in the treatment Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system
- Emerging GPCR targets for AUD: Insights from preclinical studies
protein-coupled receptors (GPCRs) are the largest group of membrane receptors in the central nervous system many drugs available on the market act via GPCRs and these receptors remain attractive targets for the treatment compounds with attractive pharmacological profiles and potential for future clinical investigation for the treatment
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
GPR110 in both central and peripheral immune cells cooperatively ameliorates neuroinflammation caused by systemic Ethanol consumption has been associated with exacerbation of neurodegenerative and systemic inflammatory PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment The GPR110 ligand synaptamide ameliorated this effect of ethanol by counteracting on the cAMP system,
- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
The NRS system has recently been validated in vivo by targeting the latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor dissociation within the developing nervous system. This tailored system aims to expedite the identification of drugs targeting the unique aGPCR receptor Sabbagh led research projects aimed on drug discovery of small molecules for the treatment of inflammatory knowledge to identify novel pharmacological targets and contribute to the development of innovative treatments
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
Methods: We disrupted the PR gene (PGR) in ERα-positive/PR-positive T-47D cells using the CRISPR/Cas9 system analyzed the gene expression profiles of PR-low and control T-47D cells in the absence of hormone and upon treatment When PR-low pools were subjected to the same hormonal treatment, up- or downregulation was either blocked
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
serotonin 5-HT2C receptor is a G protein-coupled receptor (GPCR) mainly expressed in the central nervous system mood, appetite, and reproductive behavior, it has been identified as a potential target for cancer treatment Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies
- Ep 82 with Dr. Lauren M. Slosky
multidisciplinary initiative within the University of Minnesota’s Medical School to advance research and treatment Integrating GPCR biology, behavioral pharmacology, and systems neuroscience approaches, the Slosky Lab receptor allosterism and functional selectivity can be leveraged in the development of safe and effective treatments
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
and Immunology Elucidation of active components and target mechanism in Jinqiancao granules for the treatment to elucidate active compounds in Jinqiancao granules and their target mechanisms for the potential treatment The findings provide scientific evidence for the potential use of Jinqiancao granules as a treatment
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system The results reveal that the CB2 agonist can serve as a candidate for the prevention and treatment of
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled (GPCR) signaling systems FDA-approved SFK (dasatinib) and MEK (e.g., trametinib) inhibitors in prospective clinical trials for the treatment
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
Immunology Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment integral membrane proteins that have gained considerable attention as drug targets, particularly in cancer treatment We identified a total of 265 targets associated with GG-derived bioactive compounds for the treatment hub targets, including MAPK3, SRC, EGFR, STAT3, ESR1, MTOR, CCND1, and PPARG, which demonstrate as treatment compounds and thereby paving the way for their prospective clinical applications in the field of cancer treatment
- Applying Pharmacology to Drug Discovery | Dr. GPCR Ecosystem
overall understanding of the unique science of pharmacology and how it can describe drug action in system-independent This allows predictions of drug activity in all physiological systems, not only the system where testing
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
October 23-25 Download PDF Program HERE < Back to Full Agenda Session IV AGPCRs signaling in the nervous system Neuroscience at Baylor College of Medicine, where he studies BAI1's role in the brain and the radiobiology of treatments
- Ep 12 with Dr. Antonella Di Pizio
Antonella Di Pizio, an independent research group leader at the Leibniz Institute for Food Systems Biology Antonella Di Pizio on the web Leibniz-Institute for Food Systems Biology at the Technical University
- Ep 39 with Dr. Kathryn E Livingston
Research into their mechanism of action in purified systems formed the base of her thesis work. beta-2 adrenergic receptor and developed assays to investigate real-time activity in intact cellular systems
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
Published date May 8, 2023 Abstract "Objective: Surgery injures tissue and predisposes to local and systemic functions (cytoskeletal reorganization, chemotaxis (CTX), phagocytosis, bacterial killing) in cellular systems Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models.
- Interplay between G protein-coupled receptors and nanotechnology
This significantly enhances the potency of nanoparticle delivery systems. provide a fundamental platform for developing powerful and safe GPCR-targeted drugs and nanoparticle systems ligands can modulate membrane binding and endocytosis, powerfully improving the efficacy of nanoparticle system
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
In this study, we focused on the hygrosensory, and closely related thermosensory, systems in the vinegar mechanisms underlying hygro- and thermosensation may shed light on the broader understanding of sensory systems
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
Despite advances in the treatment, many patients experience disease relapse or become refractory to treatment Talquetamab, a Food and Drug Administration-approved T-cell-directing bispecific antibody developed for treatment
- The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells
Using human induced pluripotent stem cell-derived cDC1s and a monolayer human gut organoid coculture system Our results highlight the role of GPCRs in tuning the human gut immune system according to local metabolic
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell NPFF treatment upregulates matrix metalloproteinase-9 (MMP-9) expression. Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
motor function in the body below the level of injury, is a devastating disease of the central nervous system SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune Neuraxial nerve inflammation caused by SCI persists indefinitely, blocking nerve repair; persistent system-wide
- Ep 155 with Endocrine Metabolic GPCR Organizers
crosstalk, and applying these mechanisms for distinct GPCRs in diverse physiological and pathophysiological systems Gorvin is a Wellcome Trust & Royal Society Sir Henry Dale Fellow at the Institute of Metabolism and Systems
- Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells
Treatment with the ERK-specific kinase (MEK) inhibitor U0126 and the class I PI3K inhibitor ZSTK474 decreased KS-133 reduced the percentage of cells in the S phase more than treatment with U0126 or ZSTK474 alone