Authors Sharmistha Banerjee , Taeyeop Park , Yoo Sun Kim , Hee-Yong Kim Tags Adenylyl cyclase , Cytokines

and PAR2, but not PAR4. CRISPR/Cas9 targeting of PAR1 and PAR2 combined with microarray analysis revealed genes that are regulated -knockout (KO) and PAR2-KO PC3 cells. We further examined PAR1 and PAR2 regulation of PCa cell proliferation and migration and found that absence of PAR1 promotes PC3 cell migration and suppresses cell proliferation, whereas PAR2 deficiency showed

Keith Parker to elucidate the role of steroidogenesis in regulating sexual determination and adrenal

GPCR Podcast << Back to podcast list Mark Schmeizl About Mark Schmeizl Mark leverages 30 years in various Mark believes professional placement should be about matching talented people with companies where they Mark Schmeizl on the web Website LinkedIn Dr.

Caron Tribute Part 3 About Marc Caron Dr. and neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's

Caron Tribute Part 1 About Marc Caron Dr. and neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's

Caron Tribute Part 2 About Marc Caron Dr. and neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's

Dr. GPCR Podcast << Back to podcast list Dr. Khaled Abdelrahman, Victoria Rasmussen and Madelyn Moore About Dr. Khaled Abdelrahman " Dr. Khaled Abdelrahman graduated in 2006 with a BSc in Pharmaceutical Sciences from Alexandria University (Egypt) followed by MSc in Pharmacology in the same university that was conferred in 2009. He joined the laboratory of Dr. William Cole at the University of Calgary in 2010 for his Ph.D. where he studied the molecular basis underlying altered cerebrovascular function and blood flow in type 2 diabetes. In 2015, He joined Dr. Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR) candidates that can be targeted pharmacologically to slow neurodegeneration. He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases. He is also a Registered Pharmacist in Canada and held two of the most prestigious Clinician Postdoctoral Fellowships offered by Alberta Innovates and Canadian Institutes of Health Research. He received the Canadian Society of Pharmacology and Therapeutics Postdoctoral and Publication awards along with many Young Scientist Awards from the American Society for Pharmacology and Experimental Therapeutics. " Dr. Khaled Abdelrahman on the web Twitter PubMed Google Scholar Dr. GPCR About Victoria Rasmussen "Victoria Rasmussen is a graduate fellow in Dr. Thomas Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation of G protein-coupled receptors. She completed her undergraduate education at Providence College, receiving a B.S. in Biology and a B.A. in psychology. During her time at Providence College, she received the Walsh Grant Fellowship to develop novel methods of synthesizing 2 -imidazoline scaffolds to be used as proteasome modulators in the laboratory of Travis Bethel. Victoria started her Ph.D. at the Tri-Institutional Ph.D. program in Chemical Biology, where she joined the lab of Thomas Sakmar at The Rockefeller University. She is currently working to understand the signaling and degradation of GPCRs in disease states to help test the feasibility of using protein-targeted degradation as a therapeutic strategy. " Victoria Rasmussen on the web Tri-Institutional PhD Program in Chemical Biology Rockefeller University LinkedIn Dr. GPCR About Madelyn Moore "Madelyn (Maddi) earned her B.S. in Biochemistry from the University of Minnesota-Duluth in 2020. In her time as an undergraduate, Maddi was a researcher in Dr. Amanda Klein's lab where she helped to investigate the role of various ATP-sensitive potassium channels in pain and opioid tolerance. From there, she went on to be a research technologist in Dr. Richard Vile's lab at Mayo Clinic where she aided the evaluation of tumor-specific oncolytic viruses. Maddi is currently a second year Ph.D. student in the Molecular Pharmacology and Therapeutics (MPaT) Graduate Program at the University of Minnesota. Advised by Dr. Lauren Slosky, she is working to understand the mechanism by which a new class of biased allosteric modulators for the neurotensin receptor 1 (NTSR1) act to attenuate the behavioral effects of methamphetamine." Madelyn Moore on the web MPaT PubMed LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs to bring you exciting and informative content; this short survey should take 5 minutes to fill. Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode >>

Mark Connor About Dr. Mark Connor Undergraduate BSc with Honours in Pharmacology from University of Sydney (1987, snake neurotoxins Mark Connor on the web Researchers Twitter Google Scholar Dr.

repository PMN showed GRK2 activation and cortactin deacetylation which varied with severity and was most marked Authors Hyo In Kim , Jinbong Park , David Gallo , Sidharth Shankar , Barbora Konecna , Yohan Han , Valerie

His next stop took him to Burroughs-Wellcome (BW) in Research Triangle Park (RTP) in North Carolina USA

first positive allosteric modulator (PAM) of a GPCR in the late 1980s while working at Warner-Lambert/Parke-Davis

Here, we demonstrate the overexpression of protease-activated receptor 2 (PAR2), a GPCR member in the PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. to the central role of PAR2. Akt or Etk/Bmx with PAR2. It attenuates PAR2 oncogenic activity.

I then worked at Burroughs-Wellcome in Research Triangle Park, NC (7 years) and then GlaxoSmithKline

Authors Sung Jin Park , Paul L Greer , Namgyu Lee Source Contribute to the GPCR News Coming soon Become

Vincent DiGiacomo , Mariola Ferreras-Gutierrez , Shiva Dastjerdi , Alain Ibáñez de Opakua , Jong-Chan Park

independent research career as a tenure-track Assistant Professor at Penn State University (University Park

Authors Jihong Jeong, Junhyeon Park, Geun Young Mo, Jinwoo Shin, Yunje Cho Tags GPRC5D , Multiple myeloma

I then worked at Burroughs-Wellcome in Research Triangle Park, NC (7 years) and then GlaxoSmithKline

Kyeong Jin Shin , Hyun-Jun Jang , Jin-Sun Ryu , Chae Young Lee , Jong Hyuk Yoon , Jeong Kon Seo , Sabin Park

Authors Chulo Park , Jin-Woo Lee , Kiheon Kim , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Source

mechanistic understanding of processes that control cell signaling by protease-activated receptors (PARs PARs are GPCRs that are activated through an atypical irreversible proteolytic mechanism. The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

I then worked at Burroughs-Wellcome in Research Triangle Park, NC (7 years) and then GlaxoSmithKline

Seghiri , Pradeep Kumar Singh , Hyeon Gyu Seo , Ji Yeong Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park

December 27, 2022 Abstract In patients with severe #COVID19 , increased levels of autoantibodies against PAR1 These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute

Pharmacology and Therapeutics, and Director of Graduate Studies of Experimental Therapeutics at Roswell Park Michael Feigin on the web Roswell Park Feigin Lab Google Scholar LinkedIn Twitter Dr.

Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression These observations were linked with a marked dysregulation in peritoneal lipid mediator concentrations

PARs are GPCRs that are activated through an atypical irreversible proteolytic mechanism. The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over