We summarize recent discoveries that have advanced our understanding of rod outer segment (ROS) morphology We have combined recently published cryo-electron tomography (cryo-ET) data on the ROS with structural Although hypothetical, the reconstruction of the rod phototransduction system highlights the potential roles of phosphodiesterase 6 (PDE6) and guanylate cyclases (GCs) in maintaining the spacing between ROS discs, suggesting a plausible mechanism by which intrinsic optical signals are generated in the retina

October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use Although the overall accuracy of the two non-homology-based modeling methods, AlphaFold and RoseTTAFold The official AlphaFold repository and RoseTTAFold web service were used with default settings to predict Modeller had the smallest average modeling RMSD of 2.17 Å, which is better than AlphaFold's 5.53 Å and RoseTTAFold's However, the NN-based methods (AlphaFold and RoseTTAFold) outperformed Modeller in 21 and 15 out of the

September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK The purpose of this study was to evaluate the role of dual transactivation of EGF and TGF-β receptors In addition, as an intermediary of G protein-coupled receptor (GPCR) signaling, the functions of ROCK of AG1478 (EGFR antagonists), SB431542 (TGFR inhibitor), and Y27632 (Rho-associated protein kinase (ROCK This study is the first attempt to scrutinize the significant role of ROCK in the protein expression

< GPCRs in Oncology and Immunology Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent activating its downstream signaling effectors NF-κB and MAPK to promote excessive reactive oxygen species (ROS This evoked apoptotic death of the ovarian cancer cells through the intrinsic route. Authors Niraj Nag, Tanusree Ray, Rima Tapader, Animesh Gope, Rajdeep Das, Elizabeth Mahapatra, Saibal

My addiction for dopamine led me to the Ottawa Hospital Research Institute (then the Moses and Rose Loeb pursues the study of the molecular, structural, pharmacological and signaling features of dopamine (DA druggability potential of new signaling partners we identified that drive the formation of different DA

The activation profiles of these receptors include the release of reactive oxygen species (ROS) generated Activation of the oxidase and the production of ROS are processes that are regulated by proinflammatory novel regulatory mechanisms underlying the activation of NADPH oxidase advance our understanding of the role