Search Results
279 items found for "Tatiana Da Ros"
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
We summarize recent discoveries that have advanced our understanding of rod outer segment (ROS) morphology We have combined recently published cryo-electron tomography (cryo-ET) data on the ROS with structural Although hypothetical, the reconstruction of the rod phototransduction system highlights the potential roles of phosphodiesterase 6 (PDE6) and guanylate cyclases (GCs) in maintaining the spacing between ROS discs, suggesting a plausible mechanism by which intrinsic optical signals are generated in the retina
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use Although the overall accuracy of the two non-homology-based modeling methods, AlphaFold and RoseTTAFold The official AlphaFold repository and RoseTTAFold web service were used with default settings to predict Modeller had the smallest average modeling RMSD of 2.17 Å, which is better than AlphaFold's 5.53 Å and RoseTTAFold's However, the NN-based methods (AlphaFold and RoseTTAFold) outperformed Modeller in 21 and 15 out of the
- Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK The purpose of this study was to evaluate the role of dual transactivation of EGF and TGF-β receptors In addition, as an intermediary of G protein-coupled receptor (GPCR) signaling, the functions of ROCK of AG1478 (EGFR antagonists), SB431542 (TGFR inhibitor), and Y27632 (Rho-associated protein kinase (ROCK This study is the first attempt to scrutinize the significant role of ROCK in the protein expression
- Third Rock pushes newest fund over $1B line as it marks 15 years in venture capital
June 2022 "June 15, 2022 06:30 AM EDT - In 2016, Abbie Celniker was promoted to partner at Third Rock Coming on its 15th year, Third Rock Ventures announced its sixth fund today — and largest one by far Adding it all up, Third Rock has raised $3.8 billion since its inception.
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Kosar et al. (2024) addressed this question by using the role of the Trp258 6.48 residue to guide and Furthermore, data on the role of specific residues within receptors can provide valuable insights for mutagenesis data with computational models also presents challenges, requiring high-quality data and robust Advances in bioinformatics and machine learning will play a pivotal role in addressing these obstacles Di Roberto, R. B., Chang, B., & Peisajovich, S. G. (2017).
- New role of β-arrestins in MOR signaling
highlight how G proteins and β-arrestins are involved in driving intracellular signaling and reinforce the role
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
Recently, several GPCRs have been found to play important roles in the cochlea. Moreover, Frizzleds and Celsrs have been demonstrated to play core roles in the modulation of cochlear Here, we review the key findings of GPCR in the cochlea and discuss the role of GPCR in the cochlea,
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
October 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental the regulation of cardiovascular system function and the drug target exploration, we summarize the role
- Multifunctional role of GPCR signaling in epithelial tube formation
We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing
- Multifunctional role of GPCR signaling in epithelial tube formation
We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing
- Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
We demonstrate how tail composition plays a role in modulating the binding of PI(4,5)P2 lipids to GCGR
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
2022 "Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in retinal rod To determine whether Gγ1 regulates uniquely rod phototransduction, we generated transgenic rods expressing Immunohistochemistry and Western blotting demonstrated the robust expression of each transgenic Gγ in rod cells and restoration of Gαt1 expression, which is greatly reduced in Gγ1-deficient rods. Recordings from individual transgenic rods showed that photosensitivity impaired in Gγ1-deficient rods
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and contrary, in M2 cells, octreotide failed to internalize both receptors whereas pasireotide promoted robust demonstrated that in GH3 cells SST2 and SST5 can form both homo- and hetero-dimers and that FLNA plays a role
- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
adjuvant therapy at single administration or in combinatorial human trials, arising as a good pick and roll
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Here, we focused on disclosing the integrin-dependent roles of focal adhesion kinase (protein tyrosine This work thereby supports the role of PTK2 in integrin αIIbβ3 activation and signaling."
- Immunomodulatory Role of Neuropeptides in the Cornea
As research in this area expands, further insights are made into the role of neuropeptides and their This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism These data reposition key roles of the L cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R
- Dr. Rosie Dawaliby Podcast!
🥁 Drum rolls, please! Our guest is the wonderful Dr. Rosie Dawaliby! GPCR Ecosystem paid membership ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-84-with-rosie-dawaliby
- Dr. Ross Bathgate becomes Scientific co-founder of LASEREDD Therapeutics
’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics " Ross
- Design Pharmaceuticals Closes $5 Million Pre-series A Round to Accelerate Commercialization of ...
April 2022 Design Pharmaceuticals Closes $5 Million Pre-series A Round to Accelerate Commercialization a company redesigning small molecule drug discovery, today announced the closing of a pre-series A round
- Trevena Receives up to $40M in OLINVYK ex-US Royalty-Based Financing from R-Bridge Healthcare ...
April 2022 Trevena Receives up to $40M in OLINVYK ex-US Royalty-Based Financing from R-Bridge Healthcare patients with central nervous system (CNS) disorders, today announced that the Company entered into a royalty-based
- A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent ...
A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment Like many other organs, various GPCRs play a role in regulating liver function. In particular, a better understanding of the role of GPCRs in hepatic stellate cells (HSCs), the primary In this review, we describe the functions of multiple GPCRs expressed in HSCs, their roles in liver fibrogenesis
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
We investigated the feasibility of this lipophilic entry route for 2-iodomelatonin, a nonselective agonist
- OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet ...
December 2021 OMass Therapeutics 's founder, Carol Robinson , has been awarded the prestigious Louis-Jeantet Franklin Medal in Chemistry from The Franklin Institute " Huge congratulations to our founder, Carol Robinson
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
October 2022 "Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases with high mortality, such as septicemia and meningitis. The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal and blood-brain barriers, and exert virulence are largely unknown. Human-associated bacteria encode a variety of bioactive small molecules with growing evidence for N-acyl amides as being important signaling molecules. However, only a small fraction of these metabolites has been identified from the human microbiota thus far. Here, we heterologously expressed an N-acyltransferase encoded in the obligate human pathogen N. meningitidis and identified 30 N-acyl amides with representative members serving as agonists of the G-protein coupled receptor (GPCR) S1PR4. During this process, we also characterized two mammalian N-acyl amides derived from the bovine medium. Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell types, but they also suppress the pro-inflammatory interleukin-17A+ population in TH 17-differentiated CD4+ T cells." Read more at the source #DrGPCR #GPCR #IndustryNews
- Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
September 2022 "The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily of G-protein-coupled receptors (GPCRs). FSHR is involved in reproductive processes such as gonadal development and maturation. Structurally, the extensive extracellular domain, which contains the hormone-binding site and is linked to the transmembrane domain by the hinge region (HR), is characteristic for these receptors. How this HR is involved in hormone binding and signal transduction is still an open question. We combined in vitro and in situ chemical crosslinking, disulfide pattern analysis, and mutation data with molecular modeling to generate experimentally driven full-length models. These models provide insights into the interface, important side-chain interactions, and activation mechanism. The interface indicates a strong involvement of the connecting loop. A major rearrangement of the HR seems implausible due to the tight arrangement and fixation by disulfide bonds. The models are expected to allow for testable hypotheses about signal transduction and drug development for GPHRs." Read more at the source #DrGPCR #GPCR #IndustryNews
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
genes, only neuronal RNAi knockdown of gsa-1, gpa-10, and goa-1 affected toxicity of PS-NPs in inducing ROS