or private companies) Deadlines Start of the project: now End of the project: 31 October 2022 SHORT-TERM SCIENTIFIC MISSIONS (STSM) We offer short-term scientific mission grants to Ukrainian researchers who

Screening drug candidates in terms of their computationally predicted residence times, which is a measure Additionally, we calculated the thermodynamics of ligand binding in terms of ligand binding energies

the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term

glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has remained a formidable challenge in terms

chemokine receptor 4 (CXCR4), a G-protein-coupled receptor (GPCR), has one identified natural ligand termed

In terms of pharmacology, GPCRs have been identified to exist in at least two distinct states: an active extent of their allosteric influence, an attribute that offers a considerable degree of adjustability in terms This phenomenon is termed "stimulus-trafficking," "biased agonism," or "functional selectivity" (Urban

With completion of the applicable waiting period under the HSR Act, under the terms of the License Agreement

Here, we investigate the effects that long-term CNO stimulatory culture have on hM3Dq [Ca2+]i signaling Long-term culturing under repeated CNO stimulation modified the temporal dynamics of hM3Dq [Ca2+]i signaling

Here, we engineered an antibody, termed LK30, that binds to the extracellular region of the aGPCR ADGRL3

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analysis of the currently available GPCR structures in complex with small-molecule allosteric ligands in terms

Here, we discuss recent crystal structures of inactive C5aR1 in terms of an inverted orientation of helix

Our results show that the short-term diffusion coefficient of the receptor decreases upon cholesterol

Our results show that the short-term diffusion coefficient of the receptor decreases upon cholesterol

through to Phase 1b/2a clinical proof of concept in patients, and optimize value generation • Mid-term

Their functionality in terms of cAMP production via Gαs protein coupling was decreased compared to the

Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression

Different agonists can promote differential receptor-induced signaling responses - termed bias - potentially

mechanism of inhibition of αqQ209L by YM, we developed and examined N-terminal mutants of αqQ209L, termed

Interactions in the Serotonin 1A Receptor Microenvironment Industry News Addex and Indivior Extend Research Term

Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

: Prediction of Compound-Protein Interaction by Integrating Graph Attention Network With Long Short-Term

In fact, the requirements in terms of safety margin, oral bioavailability, and frequency of administration

and chronic inflammation Developmental exposures to common environmental pollutants result in long-term

extent of their allosteric influence, an attribute that offers a considerable degree of adjustability in terms

Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term