potential. A New Wave of GPCR Drug Discovery GPCRs are considered highly druggable, with GPCR-targeting therapeutics Within the last two years, three investments stand out: · Tectonic Therapeutics: received $80 As seen below in Figure 1, natural ligands do not make use of all the potential binding contacts with About Orion Biotechnology Orion’s mission is to unlock the therapeutic potential of previously undruggable

July 2022 "July 19, 2022 07:00 AM Eastern Daylight Time BOSTON-- Tectonic Therapeutic , Inc. a pre-clinical

February 2022 " Ermium Therapeutics Announces the Formation of a Scientific Advisory Board comprising

< GPCR News < GPCRs in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 date, many small-molecule CXCR2 antagonists have entered clinical trials, showing favorable safety and therapeutic

Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic Despite its therapeutic potential, the insufficient understanding regarding of the receptor's structure and antibody recognition mechanism has impeded the progress of effective therapeutic development. only unveil the distinctive dimer organization of this unconventional Class C GPCR but also hold the potential

GPCRs in Oncology and Immunology Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic specific siRNAs inhibits the growth of cisplatin-refractory ovarian cancer xenografts, demonstrating the therapeutic potential of targeting LPAR-UCA1-let-7 axis in ovarian cancer.