gynecological malignancies, primarily due to the lack of early diagnostic tools, effective targeted therapy Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic UCA1 expression inversely correlates with survival outcomes and therapy response in ovarian cancer clinical Resistance , UCA1 , lncRNA Source Contribute to the GPCR News Coming soon Become a Contributor Classified

GPCR News < GPCRs in Oncology and Immunology Comparison of infectious complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen (BCMA)-directed therapies analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell therapy Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower

Oncology and Immunology Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy The potential for precise tumor diagnosis and targeted therapy through therapeutic targeting of olfactory

Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy We evaluated infections in 99 adults who received a first BCMA-directed CAR T-cell therapy (commercial patients (37%) experienced 64 infectious events over the first year after BCMA-directed CAR T-cell therapy Respiratory infections predominate after BCMA CAR T-cell therapy, particularly after day 100.

many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy The review culminates by illuminating emerging therapies and discussing innovative strategies to harness

News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy promotes the secretion of chemokines and polarizing factors through activating PI3K/AKT/NF-κB pathway, thereby Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy

March 2, 2024 Abstract " Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer (NSCLC) and overcoming drug resistance to molecular-targeted therapies. insights support the role of RGS20 as a promising novel molecular marker and a target for future targeted therapies

continues with the basics learned in Course 1 and extends the ideas to apply GPCR utilization in drug therapy messenger production (i.e., calcium, cAMP), and these new behaviors are being used to create novel GPCR therapies Register today! Early-bird registration is over.

heterogeneity of acute myeloid leukemia (AML) has challenged the development of precise and effective therapies The objective of this study was to elucidate the genomic basis of drug resistance or sensitivity, identify Results: We detected genetic signatures associated with sensitivity or resistance to specific agents,

Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

Due to the urgency of finding therapies for post-COVID-Syndrome (PCS), we report here the interim results controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell depletion therapy

continues with the basics learned in Course 1 and extends the ideas to apply GPCR utilization in drug therapy messenger production (i.e., calcium, cAMP), and these new behaviors are being used to create novel GPCR therapies

SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis with CR combined with targeted therapy between SSTR2 and EGFR in NPC and provides new insights into the potential benefits of EGFR targeted therapy

While the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies demonstration of the involvement of PAR PH binding motif signaling in ovarian cancer and Pc(4-4) as a potential therapy

centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies

episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and combination therapies

In insulin-resistant HF patients, AT2R autoantibodies were decreased (r = -.240, P < 0.05), and AT1R cardio-pathogenic role of GPCR autoantibodies and suggest that further investigations are required before specific therapies

new knowledge to find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies

Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered therapies

of functional imaging targeting aberrant GPCRs should be useful for identification and for specific therapies

Essential information is needed to characterize a drug's profile aimed at therapy.

This established Peptidase M84 as a drug candidate for receptor mediated targeted-therapy of ovarian

overactivation, along with that of downstream regulators, presents a potential target for novel anticancer therapies

These mice can then be used to test dietary regimens, drugs, and adenoviral gene therapies for their

structure offers insights for optimizing antibody design against GPRC5D for relapsed or refractory MM therapy

the Beaulieu Lab has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy