August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology characterized this H3R biosensor on intact cells by monitoring the effect of consecutive ligand injections in time

Using time-resolved cryo-electron microscopy (cryo-EM) and variability analysis to monitor the transitions Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024).

Come attend this month's virtual café talk to see the awesome work of Dr. Stuart Maudsley on how an aging physiological context affects #GPCR signaling #drgpcr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

The silencing efficiency of siGPRC5A was evaluated by real-time fluorescence quantitative PCR (RT-qPCR Meanwhile, RT-qPCR results showed that the gene expression levels of GPRC5A at different time point ( 2, 6, 12, 24 h) in LPS-induced GFs (0.026±0.002, 0.042±0.005, 0.004±0.000, 0.016±0.000) were upregulated group (0.004±0.000, 0.004±0.000, 0.002±0.000, 0.007±0.000) (all P<0.001), respectively, and peaked at 6 h. Authors Y H Hu , L L Shang , S H Ge Source Contribute to the GPCR News Coming soon Become a Contributor

to optimize compound selection for screening, and in 1997 switched to computational chemistry full-time Bruns has over 80 publications and 11,000 citations, with an h-index of 47. Dr. Robert F.

Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K Authors Carolina Montañez-Miranda , Riley E Perszyk , Nicholas H Harbin , Jennifer Okalova , Suneela