Start off your program by giving some basic information about what participants can expect to learn. Introduce the topic and provide a basic outline of what's to come. Consider adding a questionnaire to ask participants what they hope to take away from the experience, or a quiz to test their understanding before getting started.

September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P1-5. Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor In this article, we describe a 2.2 Å resolution room temperature crystal structure of the human S1P5 receptor demonstrates a unique ligand-binding mode, involving an allosteric sub-pocket, which clarifies the receptor

influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors within myotubes and tissues of skeletal muscle from both murines and humans, thus representing a potentially The impact of ACEA is inhibited by the selective CB1 receptor antagonist, rimonabant. The present research demonstrated that 10 nM of ACEA notably amplified mRNA gene expression of NR4A1 and NR4A3; this effect was suppressed by the addition of 100 nM rimonabant.

September 2022 "Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute decreased TrkB autophosphorylation, preventing its activation with agonist 7,8-DHF, even with low 5-HT2A receptor A blockade of 5-HT2A receptor with the preferential antagonist ketanserin prevented the receptor-mediated Our data reveal the functional role of 5-HT2A–TrkB receptor heterodimerization and suggest that the regulated

, Interferon-gamma , Interleukin , Interleukin-1 receptor alpha P , Interleukin-13 receptor , Interleukin -13 receptor alpha 1/2 , Interleukin-31 receptor , Interleukin-31 receptor A , Interleukin-33 receptor , Transient receptor potential , Transient receptor potential ankyrin 1 , Transient receptor potential cation channel subfamily M member 4 , Transient receptor potential cation channel subfamily M member 8 , Transient receptor potential vanilloid 1 , US Food and Drug Administration , VIP , Vasoactive intestinal

Immunology A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential In this scenario, metabolite-sensing G-protein coupled receptors (GPCRs), involved in several biological The role of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial Besides, when GPR109A was transiently silenced, the mRNA expression and secretion of IL-1β, IL-6 and A better understanding of metabolite-sensing GPCRs, such as GPR109A, could establish their potential

in cancer Published date December 12, 2023 Abstract "Odorant receptors, traditionally associated with Alongside the canonical GPCR odorant receptors, dysregulation of non-canonical odorant receptors such These findings shed light on the potential of non-canonical odorant receptors as therapeutic targets comprehensive overview of the intricate relationships between these chemoreceptors and various types of cancer, potentially Ultimately, this review discusses the potential development of novel therapeutic strategies targeting