September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model antibody atezolizumab and nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

and inflammation, all of which are influenced by the cellular and molecular microenvironment of the tumor techniques, have been tested to reduce the malignancy and generate a harmful microenvironment for the tumor therapeutic benefits of the β-adrenergic receptor antagonist, propranolol, were described in benign tumors

Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in tumor live-imaging modalities, and displayed high efficiency when used to label complex 3D cellular systems such as tumor A2BAR as a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor

Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing a close relationship with tumor initiation and progression. The potential for precise tumor diagnosis and targeted therapy through therapeutic targeting of olfactory cell proliferation , Tumor development , Tumor metastasis .

P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis , and affect the tumor immune microenvironment (TIME) and tumor drug resistance, which is conducive to We explored the role of P2Y12R inhibitors in different tumors and the latest advances by summarizing the basic and clinical studies on the effects of P2Y12R inhibitors on tumors." , Tumor microenvironment Source Contribute to the GPCR News Coming soon Become a Contributor Classified

typical GPCR with a high affinity for adenosine, is widely expressed on immune cells, inhibiting anti-tumor Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages We hypothesize that blocking A2aR on LUAD cells will inhibit the role of TAMs and control tumor growth Functionally, blocking A2aR significantly suppresses TAMs infiltration and attenuates tumor burden in