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ability to perform, understand, and communicate GPCR pharmacology data analysis to a high level, as well

August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs).

One suggested theory is that cannabinoids regulate a variety of physiological processes within the cells Murine L6 skeletal muscle cells were used in order to clarify additional possible molecular signaling Skeletal muscle cells have often been used; it is well-documented that they express cannabinoid receptors In the current work, it is demonstrated that skeletal muscle cells exhibit functional expression of CB1 Thus, in skeletal muscle cells, a possible physiological expression of CB1 receptors was identified.

We investigated whether melatonin receptors are expressed on airway smooth muscle; whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation. muscle and cultured human airway smooth muscle (HASM) cells by RT-PCR, immunoblotting, and immunohistochemistry MT2 agonist ramelteon (10 µM) significantly inhibited forskolin-stimulated cAMP accumulation in HASM cells

< GPCR News < GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic heterogeneity and vascular However, its role in normal and tumor vascular remodeling is controversial. The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor

Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at

< GPCR News < GPCRs in Oncology and Immunology Single cell G-protein coupled receptor profiling of Transcription Key results: Transcription factor 21 (Tcf21)+ cells that expressed 2 or 3 of Postn, Acta2 and Pdgfra Tcf21+ α-smooth muscle actin (α-SMA)+ interstitial cells accumulated in the kidneys of mice with UUO TCF21, ADGRA2, S1PR3 and ADORA2A/2B were each detectable in α-SMA+ interstitial cells in human kidneys Study of GPCRs expressed by these cells may identify new opportunities for CKD therapeutics. " Authors