August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology

This year Arum Wu et al. reported a library of Nbs to study the allosteric modulation of the rhodopsin H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology. Science (New York, N.Y.), 347(6226), 1113–1117. https://doi.org/10.1126/science.aaa5026 Wu, A., Salom

peroxidase enzyme that catalyzes the oxidation of specific substrates in the presence of hydrogen peroxide (H When AUR is oxidized by APEX2 in the presence of H 2 O 2 , it produces a fluorescent product that can

., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. G., & Schiöth, H. B. (2003). M., Pérez-Hernández, G., Batebi, H., Gao, Y., Eskici, G., Seven, A.

Unlike LGR2 in other insect species, HLGR2 was found to play a crucial role in the control of H. cunea Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.

than 60 ORs in the testis and only a few ORs in the liver (Flegel C. et al. 2013; Maßberg D. and Hatt H. although there are highly increased in prostate tissue, especially in prostate cancer (Maßberg D. and Hatt H. olfactory-specific chaperones to be correctly targeted to the surface of heterologous cells (Maßberg D. and Hatt H.

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will facilitate further development of therapeutic agents targeting the DOR.Communicated by Ramaswamy H.

F et al. 2021, Chen, H. et al. 2022). H., & Lee, J. H. 2020, Casiraghi, M. et al. 2019), double electron-electron resonance (DEER) spectroscopy for high-resolution

expression, restoration to ≥57% of WT levels was achieved for 6 by treatment with 1 µM CAN1404 for 24 h,

Of 161 molecules tested, 42 substituted more than 50% of [³H]-LSD at 10 μM, achieving a 26% hit rate.

October 21st to 27th, 2024 Industry News UNC School of Medicine to Receive $3-Million Award from ARPA-H’

Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy Z., Wilderman, A., Katakia, T., McCann, T., Yokouchi, H., Zhang, L., Corriden, R., Liu, D., Feigin, M

"We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg

their fantastic work on Germline mutations in a G protein identify signaling cross-talk in T cells Victoria

Zhang, H., et al., Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic

H., Heydenreich, F. M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K.

., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z., Huang, Z., & He, Y. (2022).

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George H. Edmond H.

of a small protein GPCR ligand using new peptide chemistry technology and rational design Gaertner, H.

Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) Confo Therapeutics CEO, Cedric Ververken, will join WuXi