employ to manipulate the immune system, translocate the mucosal and blood-brain barriers, and exert virulence

October 2022 "Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells to benefit Most acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors US27, US28, UL33, and UL78; human herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus

the GprC-AcyA pathway Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence

The hepatitis B virus X protein (HBx) is involved in the process of hepatocellular carcinoma via the protein-coupled receptors; GST: glutathione S-transferase; HCC: hepatocellular carcinoma; HBV: hepatitis B virus ; HBx: hepatitis B virus X protein; HMGB1: high mobility group box 1; HIF1A/HIF-1α: hypoxia inducible

Biotechnology Inc. and Trevena Inc. could offer potential new weapons against omicron and future viral The omicron strain of the virus was first identified in South Africa in early November, and an existing

Animal models of CMV provide insights into their role in viral fitness. The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and Understanding the relevance of the viral GPCR signalling profiles for in vivo function will provide

GPCRs in Oncology and Immunology Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin -8 to Facilitate Viral Replication by Regulating Ca2+ Flux.

Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication

mutation in exon 6 of the CaSR gene Reviews, GPCRs, and more Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41 Structural and Molecular

CCR5), a major receptor in inflammation and the principal entry co-receptor for Human Immunodeficiency Viruses

Our approach, described in detail here, uses adeno-associated viruses infused intracerebrally in order

Structural characterization of biologics, such as vaccines, viral vectors, and gene therapy agents, has

astrocytes of a lipopolysaccharide (LPS)-induced neuroinflammation mouse model using adeno-associated viruses

, a division of Twist Bioscience , that neutralizes all known variants of concern of the SARS-CoV-2 virus

Retrograde trans-synaptic rabies virus tracing revealed that postsynaptic cAMP signaling is required

Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to

Specialized Pro-resolving Lipid Mediators and Resolution of Viral Diseases.

activation PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer A virally

CKRs can be classified into typical CKRs, atypical CKRs (ACKRs) which lack G-protein signaling, and viral Constitutive Activity of the viral CKR US28 and “Chemokine Scavenger” ACKR3 Both US28 and ACKR3 are constitutively

metabolomics: New insights into pregnenolone function Molecular characterization of lumpy skin disease virus

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.

mechanisms, functions, and therapeutic targets. β-arrestins and G protein-coupled receptor kinases in viral

A Perspective on Class C GPCR Based Genetically Encoded Biosensors Emergence of lumpy skin disease virus

First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India

Other examples of O-glycosylation impact on chemokine receptors include the viral receptor US28 (Bagdonaite