For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and

For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and

pathways, particularly those involving β-arrestins, which are now proving significant in drug discovery (Wei Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R.

., Weis, W. I., & Kobilka, B. K. (2011). C., Gmeiner, P., Steyaert, J., Weis, W. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013).

N7.49P7.50xxY7.53 and D3.49R3.50Y3.51 motifs, located near the intracellular ends of TM7 and TM3, respectively (Weis and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu, Zhao namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao

In particular, focus lies on the mechanism behind the techniques, and the specific advantages and challenges

Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy

Rational Drug Design One immediate application of this research lies in rational drug design .

between the receptor-Gs and receptor-Gi complexes, suggesting that the selectivity of the G-protein lies

Li, et al 2012; B. Bai, et al. 2014; B. Ji, et al. 2020; L. Wan, 2020).

Zhao et al. 2019). Zhao et al. 2019) together with confocal fluorescence microscopy.

Overall, the future potential lies in using different therapeutic modalities to modulate the stromal

This week's highlight includes congrats to: Ya-Tzu Li for her contributor article titled Do You Believe

., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H., Xiong, Y., Zhang, A., Guo

Zhao, P., et al., Activation of the GLP-1 receptor by a non-peptidic agonist. 

This PTM has been shown to be heterogeneous [Li X et al. 2018; Scurci I et al. 2021) and to improve the

For example, OR4M1 was proposed to interfere with aberrant tau hyperphosphorylation (Zhao W. et. al 2013

Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling

Through developing a high-resolution method, Hao Chen et al. directly visualized the fusion of vesicles