Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified in WHIM Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and compare the properties of S339fs5 with wild type CXCR4 and a previously identified WHIM Taken together, these studies identify a new WHIM syndrome mutant, CXCR4-S339fs5, that promotes enhanced

N7.49P7.50xxY7.53 and D3.49R3.50Y3.51 motifs, located near the intracellular ends of TM7 and TM3, respectively (Weis and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu, Zhao namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao

For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and

For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and

pathways, particularly those involving β-arrestins, which are now proving significant in drug discovery (Wei Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R.

Zhao et al. 2019). Zhao et al. 2019) together with confocal fluorescence microscopy.

., Weis, W. I., & Kobilka, B. K. (2011). C., Gmeiner, P., Steyaert, J., Weis, W. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013).

Zhao, P., et al., Activation of the GLP-1 receptor by a non-peptidic agonist. 

Chemokine–Chemokine Receptor Complexes Industry News Mavorixafor reduces infection rates among patients with WHIM

Placebo in Participants Diagnosed with WHIM Syndrome GPCR Events, Meetings, and Webinars ASPET 2023 -

For example, OR4M1 was proposed to interfere with aberrant tau hyperphosphorylation (Zhao W. et. al 2013

Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling

Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy

Through developing a high-resolution method, Hao Chen et al. directly visualized the fusion of vesicles

Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen