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573 items found for "Wenmiao Li"

Programs (1)

  • GPCRs in Pharmacology

    Whether you are a healthcare professional, researcher, or student in the life sciences, this course will

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Posts (368)

  • Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...

    October 2022 Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric tissue response to a given dose of the hormone or its antagonist depends on receptors that engage the ligand Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution. , X-ray structures of both AngII receptors (AT1 and AT2 receptors) bound to peptide and non-peptide ligands Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus

  • Endogenous ligand recognition and structural transition of a human PTH receptor

    Intriguingly, the two ligands have distinct signaling and physiological properties: PTH evokes prolonged The distinct molecular actions are ascribed to the differences in ligand recognition and dissociation A comparison of the PTH-bound and PTHrP-bound structures reveals distinct ligand-receptor interactions underlying the ligand affinity and selectivity. dissociation from the receptor and shed light on the distinct durations of signaling induced by PTH

  • Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...

    October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz Previous assays verified that a typical G protein-coupled receptor, β-adrenergic-like octopamine receptor

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