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90 items found for "Wilms tumor"

Posts (59)

  • Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

    September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model antibody atezolizumab and nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

  • Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies

    and inflammation, all of which are influenced by the cellular and molecular microenvironment of the tumor techniques, have been tested to reduce the malignancy and generate a harmful microenvironment for the tumor therapeutic benefits of the β-adrenergic receptor antagonist, propranolol, were described in benign tumors

  • Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...

    Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in tumor live-imaging modalities, and displayed high efficiency when used to label complex 3D cellular systems such as tumor A2BAR as a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor

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  • Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy

    Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing a close relationship with tumor initiation and progression. The potential for precise tumor diagnosis and targeted therapy through therapeutic targeting of olfactory cell proliferation , Tumor development , Tumor metastasis .

  • A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages

    typical GPCR with a high affinity for adenosine, is widely expressed on immune cells, inhibiting anti-tumor Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages We hypothesize that blocking A2aR on LUAD cells will inhibit the role of TAMs and control tumor growth Functionally, blocking A2aR significantly suppresses TAMs infiltration and attenuates tumor burden in

  • GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment

    News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in the tumor In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis. Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery

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