September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model antibody atezolizumab and nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

and inflammation, all of which are influenced by the cellular and molecular microenvironment of the tumor techniques, have been tested to reduce the malignancy and generate a harmful microenvironment for the tumor therapeutic benefits of the β-adrenergic receptor antagonist, propranolol, were described in benign tumors

Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in tumor live-imaging modalities, and displayed high efficiency when used to label complex 3D cellular systems such as tumor A2BAR as a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor

GPCRs in Oncology and Immunology Exploiting frequent and specific expression of PRL3 in pediatric solid tumors Published date September 21, 2023 Abstract "Phosphatase of regenerating liver 3 (PRL3) is a specific tumor However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association Su-Fern Seng , Prasad Iyer , Pei Ling Chia , Shui Yen Soh , Qi Zeng Tags PRL3 , PTP4A3 , PRL3-zumab , Wilms tumor , neuroblastoma , non-rhabdomyosarcoma soft tissue sarcoma , osteosarcoma , pediatric tumors ,

< GPCRs in Oncology and Immunology Aberrant hormone receptors regulate a wide spectrum of endocrine tumors of diverse GPCRs and their ligands play an important role in the over-function of various endocrine tumours ; AVPR2, D2DR, and SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin receptors in medullary thyroid carcinoma; and SSTRs, GLP1R, and GIPR in other neuroendocrine tumours. to cortisol-secreting adrenal lesions, but also occurs in tumours of several other organs."

and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors characteristics of growth hormone (GH)-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors Gene ontology analysis was performed for differentially expressed proteins between wild-type and mutant the GH change rate in the octreotide loading test, and WWC3, SERINC1, and ZFAND3 correlated with the tumor