April 2022 Sosei Heptares Confirms Senior Leadership Changes to Drive the Company Through the Next Stage Sosei Group Corporation (“the Company”; TSE: 4565) today confirms that a series of Executive Management changes

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic

In this study Xin Cai et al. highlight the importance of GPCR dimers in drug discovery referring to important conformational changes, allosteric properties, ligand and functional selectivity. But what are the conformation changes that drive GPCR dimerization? The interaction between two receptors in a dimer involves a conformational change in the transmembrane Interestingly, the amplitude of the conformational changes due to ligand binding is limited at these

Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang ,

Authors Pedram Shafiei-Jahani, Shi Yan, Mohammad H Kazemi, Xin Li, Amitis Akbari, Kei Sakano, Yoshihiro

Drug combination effects on protein changes in the cell cycle- and apoptosis pathways contribute to the Authors Xin Miao , Gilbert Koch , Shichen Shen , Xue Wang , Jun Li , Xiaomeng Shen , Jun Qu , Robert