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140 items found for "Yanbin Ke"
- Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger, was appointed...
December 2021 Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger , was
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent We generated mutant mouse lines lacking the entire Defensin (Def) gene cluster in keratinocytes or Mrgpra2a
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions The kinase GRK2 and the multifunctional scaffolding protein β-arrestin2 are key integrated signaling
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
We demonstrate with the application of ML methods that it is possible to identify the key interactions
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo Taken together, these data demonstrate that key features of the MCMV lifecycle are coordinated in diverse
- Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity and antibody production during infection. Aberrant EBI2 signaling is implicated in inflammatory bowel disease, sclerosis, and infectious disease. Here, we report the cryo-EM structures of an EBI2-Gi signaling complex with its endogenous agonist 7α,25-OHC and that of an inactive EBI2 bound to the inverse agonist GSK682753A. These structures reveal an agonist binding site for the oxysterol and a potential ligand entrance site exposed to the lipid bilayer. Mutations within the oxysterol binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell migration indicating that G protein signaling directly involves in the oxysterol-EBI2 pathway. Together, these findings provide new insight into how EBI2 is activated by an oxysterol ligand and will facilitate the development of therapeutic approaches that target EBI2-linked diseases." Read more at the source #DrGPCR #GPCR #IndustryNews
- Dr. Kevin Pfleger and Dr. Elizabeth Johnstone were awarded one of the 2022 Diabetes Research...
Kevin Pfleger and Dr. " Congratulations to Perkins Professor Kevin Pfleger and Dr Elizabeth Johnstone who were awarded one
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
Terry Kenakin and Sam Hoare ! Terry Kenakin to gain insights and prepare for upcoming courses. Kenakin's upcoming courses. Our goal is to ensure that education is within reach for everyone!
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
The Principles of Pharmacology I & II BUNDLE is your key to mastering the field. Terry Kenakin and Sam Hoare ! Terry Kenakin as he shares insights into what you can anticipate for the upcoming courses. Kenakin's upcoming courses. Our goal is to ensure that education is within reach for everyone!
- GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024
Terry Kenakin and Sam Hoare ! Terry Kenakin on what to anticipate for these courses! Kenakin's upcoming classes. We’re committed to making education accessible to all!
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
Kenakin and Hoare on ' Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR ligands (affinity, efficacy, co-operativity) Determining mechanisms of action for new GPCR ligands Key Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key
- Enhancing GPCR Research Outreach | Dr GPCR University early-bird registration ends soon!
Terry Kenakin with our premium membership and enjoy a 1-month FREE trial! Terry Kenakin Reading Materials Access to the private group Certificate of participation Learn the essentials more Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key
- Dr. GPCR University registration is now open! Secure your spot now!
Terry Kenakin ! Terry Kenakin Reading Materials Access to the private group Certificate Explore: Key metrics for assessing
- Exploring the Breakthroughs in GPCR Research
Terry Kenakin .
- 📰 GPCR Weekly News, July 1 to 7, 2024
Terry Kenakin . Mark your calendars because registration opens on July 18, 2024!
- 📰 GPCR Weekly News, June 24 to 30, 2024
Terry Kenakin will lead two brand-new, back-to-back courses tailored for the Dr. This key event will delve into adhesion GPCR Biology.
- 📰 GPCR Weekly News, June 17 to 23, 2024
Terry Kenakin will conduct two back-to-back courses this fall.
- Do You Believe AI Could Accelerate Drug Discovery?
For the 5-HT2A receptor, AF2 models showed some variations at key residues, and docking 1.6 billion molecules To fully harness these benefits, it is essential to keep updating and refining the databases with high-quality
- 📰 GPCR Weekly News, June 10 to 16, 2024
Terry Kenakin will conduct two consecutive courses in September and October 2024. Join us in vibrant Mexico City from October 23 to 25, 2024, for this key event in adhesion GPCR Biology
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling Terry Kenakin will return for two consecutive courses in September and October 2024. Desensitization of G Protein-Coupled Receptor RNA-seq screening and gene function analysis uncover GPR183 as a key
- Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
pull down, and transwell cell migration assays to investigate the effects of these modifications on key Key findings include: Phosphorylation Hotspots: P Loop (Ser44, Ser47, Thr48): Impairs ligand-stimulated
- 📰 GPCR Weekly News, May 27 to June 2, 2024
Terry Kenakin will return for two consecutive courses in September and October 2024. Chemotactic Cytokines June 4, 2024 | Live Webinar ‘It All Starts With a Protein – Protein Sciences as a Key
- 📰 GPCR Weekly News, May 20 to 26, 2024
Terry Kenakin will return for two consecutive courses in September and October 2024. Chemotactic Cytokines June 4, 2024 | Live Webinar ‘It All Starts With a Protein – Protein Sciences as a Key
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
While these signaling pathways are highly interconnected, they can also be regulated independently (Kenakin Kenakin, T. (2019). Biased receptor signaling in drug discovery.