Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole Daly

Jianming Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Yao Lu, Drs Christopher Langmead,  Gregory Stewart, et al. for their study on Molecular insights into orphan

August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling We found that preincubation and luminescence reading at room temperature were optimal as compared to

proteins (Gether 2000), with numerous intermediate sub-states in between (Vauquelin and Van Liefde 2005; Yao 1984 (Cerione et al. 1984), where reconstitution of purified β2-adrenergic receptors from guinea pig lung

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case Reference Cam Sinh Lu. (2024, September 3).

factors, including ETS, c-Jun, and Fos, modulating gene expression and influencing cellular functions (Lu Lu, N., & Malemud, C. J. (2019). S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).

This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh Lu

This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu

This week's highlight includes congrats to: Cam Sinh Lu, for his first Dr.

TM7 and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu constitutively active receptors, meaning they can signal independently of agonist (Casarosa, Bakker et al. 2001, Luker recycling of chemokines without activating G-protein pathways (Randolph-Habecker, Rahill et al. 2002, Luker

Jack Antel to its clinical advisory board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues

odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis

article on Profiling Immune Cell and Platelet Transcriptomes , and we want to wish her the best of luck leveraging GPCR expertise as a discovery engine - multiple partners have already signed on to the science Lundbeck

Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated Calcium Entry in the Lung

management, driving the obesity market toward $66 billion by 2030 and on track to become one of the most lucrative

Lukas Grätz , Jan Voss , and Gunnar Schulte , for their study on Class-Wide Analysis of Frizzled-Dishevelled

Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Deciphering the genetic landscape of lumpy $4.6 Million in Milestone Payments from Centessa Pharmaceuticals CB1 receptor inverse agonist improves lung

Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs while executing your best perreo or Luis Enrique’s “Yo no sé mañana” while a stranger takes you floating

FRET and BRET sensors operate on the principle of energy transfer between a fluorescent or luminescent Luttrell, and M.H. Lee, Probing Arrestin Function Using Intramolecular FlAsH-BRET Biosensors. 

This week's highlight includes congrats to: Luca Franchini and Cesare Orlandi for their research on Deorphanization

Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target Gunnar Schulte, Lukas

., Lundin, L. G., & Schiöth, H. B. (2003).

al. for their research on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers

prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung

., Luttrell, L. M., & Lefkowitz, R. J. (2003).

elegan Species-Specific Duplicated FMRFaR-like Gene A62 Regulates Spontaneous Locomotion in Apolygus lucorum A Perspective on Class C GPCR Based Genetically Encoded Biosensors Emergence of lumpy skin disease virus

for FY2023 Financial Results Novartis Automates New Radioligand Therapy Production Plant Novartis’ Lutathera

nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction Industry News Novartis Lutathera