, Weirong Zhan, Dandan Guo, Haizhen Lin, Muhammad Asad Farooq, Chenxu Jin, Li Zhang, Ying Zhou, Jie Yao

Authors Han Zhou, Tao Hou, Aijin Shen, Wenyi Yu, Liangliang Zhou, Wenjie Yuan, Wanxian Wang, Yumin Yao

During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the GPCR About Cam Sinh Lu Cam Sinh Lu is a PhD student at Monash Institute of Pharmaceutical Sciences, Monash Cam Sinh Lu on the web LinkedIn Dr.

The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations Authors Miao Guo , Yan Zhang , Lehao Wu , Ye Sheng , Jiaqi Zhao , Zeyuan Wang , Huiyu Wang , Lu Zhang

Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov, Junke Zheng, Mingyao Liu, Weiqiang Lu

Dai , Wen-Fang Wang , Hao Zhang , Chao-Fu Wang , Tong Yin , Shu Cheng , Hui-Juan Zhong , Shan-He Yu , Lu

Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss .

Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou

< GPCR News < GPCRs in Oncology and Immunology Deciphering the genetic landscape of lumpy skin disease virulence through comprehensive genome sequence analysis in India Published date May 23, 2024 Abstract "Lumpy Sai Balaji, V Gairola, D Poloju, S Gulzar, K P Singh, R K Singh, G K Sharma Tags Genome sequence , Lumpy

News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung protein-coupled receptor (GPCR)-related genes and differentially expressed genes (DEGs) in an acute lung RGS6 plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung Li , Cuicui Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung Published date July 3, 2023 Abstract "Despite campaigns and improvements in detection and treatment, lung One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed Since lung cancer is often diagnosed in advanced stages, our efforts should focus on early diagnosis, Furthermore, their modulation could be considered as a promising approach in lung cancer therapeutics

G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell lung

< GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) We hypothesize that blocking A2aR on LUAD cells will inhibit the role of TAMs and control tumor growth Constructing models of TAMs and LUAD mice, we find that A2aR highly expressed on LUAD cells promotes blockade of A2aR may support a novel and potent therapeutic option for LUAD."

Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung Van Meir pursued postdoctoral work at the Ludwig Institute for Cancer Research in San Diego and joined

Authors Chakit Arora, Marin Matic, Luisa Bisceglia, Pierluigi Di Chiaro, Natalia De Oliveira Rosa, Francesco Carli, Lauren Clubb, Lorenzo Amir Nemati Fard, Giorgos Kargas, Giuseppe R Diaferia, Ranka Vukotic, Luana

Julia Tutzauer , D Stephen Serafin , Tobias Schmidt , Björn Olde , Kathleen M Caron , L M Fredrik Leeb-Lundberg

Either GRK2 or HDAC inhibition prevented loss of mouse lung bacterial clearance, but only the combination

Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 signalling in mesenchymal cells, which is imperative for normal alveologenesis and maintenance of lung Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .

Kussmaulallee 12, 91054 Erlangen, Germany 2 Developmental Genetics, Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany 3 Department of Developmental Biology, Washington Immunoblots on wild-type and Adgrb1 exon 2-deleted mice, reverse transcription PCR and promoter-luciferase We previously demonstrated that kidney-specific Adgrf5/Gpr116 knockout causes luminal membrane accumulation James Bridges at National Jewish Health in Denver, CO researching molecular mechanisms of lung injury

de Lourdes Ochoa-González, Martín Zapata-Zúñiga, Eduardo Mondragon-Marín, Edgar E Lara-Ramírez, Jose Luis

be used as a biomarker and a new target for diabetes and that CXCR2 antagonists may also attenuate lung

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss,

Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung

CELSR1 is reactivated in luminal-type ductal carcinomas. Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas specific hypothesis that biased expression of CELSR1 isoforms will predict invasive potential of a luminal tumour invasive mechanism (b) quantify CELSR1 isoform expression (mRNA and protein) within patient luminal

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

Authors Mor Oron-Herman , David Kirmayer , Amelie Lupp , Stefan Schulz , Genady Kostenich , Michel Afargan

formation in human intestinal dendritic cells Published date October 29, 2024 Abstract "The intestinal lumen G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut luminal human gut organoid coculture system, we show that cDC1s extend their dendrites toward pyruvate on the luminal activation via pyruvate enhances the fundamental function of cDC1 by allowing efficient uptake of gut luminal

Authors Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans ,