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of the majority of marketed drugs, the poor pharmacokinetics and physicochemical properties of GPCR ligands greatly limit their clinical applicability. Nanotechnology, as versatile techniques, can encapsulate GPCR ligands to assemble synthetic nano-GPCRs Moreover, endosomal delivery of GPCR ligands by nanoparticles can precisely initiate sustained endosomal Authors Yuhong Jiang , Yuke Li , Xiujuan Fu , Yue Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun

GPCR Podcast << Back to podcast list Dr. Robert J. Duke Professor of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University His legacy lies in the numerous discoveries he and his team made in the GPCR field and in all those who GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

, Hao Zhang , Chao-Fu Wang , Tong Yin , Shu Cheng , Hui-Juan Zhong , Shan-He Yu , Lu Jiang , Sheng-Yue Wang , Hai Fang , Rui-Hong Zhang , Yue Zhu , Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment , Multi-omics

The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule A journey from Duke From 91 to 94, he was an assistant professor at Duke University in North Carolina, working with Marc Brunos Giros on the web The Douglas Research Centre McGill University Pubmed Google Scholar LinkedIn

GPCR Podcast << Back to podcast list Julia Gardner About Julia Gardner Julia is a senior undergraduate student at Duke University, where she studies chemistry and Chinese. Julia Gardner on the web Rajagopal Lab Google Scholar ResearchGate LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Authors Xiaoyan Ding , Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo

< Back to Full Agenda Session II AGPCR signaling pathways and trafficking Localization of putative ligands ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Pal Kasturi Localization of putative ligands Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial His research interest lies in understanding the molecular basis for human tumor development and how to ADGRG6 NTF has multiple extracellular domains like CUB, PTX, SEA, hormone binding domain, and the GAIN

GPCR Podcast << Back to podcast list Dr. Sudha Shenoy About Dr. Sudha Shenoy Dr. Lefkowitz (Nobel Laureate, 2012) at Duke University. Dr. Sudha Shenoy LinkedIn Pubmed Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

receptor (EGFR) belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked Conclusion: Our study is the first to shed light on the intricate relationship between SSTR2 and EGFR Authors Yue Xu, Zihan Quan, Yuting Zhan, Haihua Wang, Jiadi Luo, Weiyuan Wang, Songqing Fan Tags biomarkers

He then joined the Internal Medicine Residency training program at Duke University Medical Center. Lefkowitz, where his research focused on biased agonism, with the development of approaches to quantify ligand After completing his training, he joined the faculty at Duke, with a focus on the mechanisms underlying His group and others have shown that many of these ligands act as biased agonists for the same receptor Sudarshan Rajagopal on the web The Rajagopal Lab Google Scholar Pubmed LinkedIn Dr.

GPCR Podcast << Back to podcast list Dr. Sudarshan Rajagopal About Dr. Sudarshan Rajagopal Dr. He then joined the Internal Medicine Residency training program at Duke University Medical Center. completing his training in clinical cardiology, he started as an Assistant Professor of Medicine at Duke disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Sudarshan Rajagopal on the web LinkedIn Website Google Scholar LinkedIn Dr.

secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren

GPCR Podcast << Back to podcast list Dylan Eiger About Dylan Eiger Dylan Eiger is currently an MD/Ph.D . student at Duke University School of Medicine. He received his B.S. in Chemistry from Duke University in 2016 where he worked in the lab of Dr. He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus Dylan Eiger on the web LinkedIn Twitter PubMed Website Dr.

GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression, thereby modulating lipid Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 Authors Jiamin Zhou, Xigan He, Weixing Dai, Qingguo Li, Zhen Xiang, Yixiu Wang, Ti Zhang, Weiqi Xu, Lu Wang, Anrong Mao Tags Ferroptosis , GPR37 , Lipid metabolism , SCD1 , p38 Source Contribute to the GPCR

GPCR Podcast << Back to podcast list Dr. Nicolas Gilles About Dr. Nicolas Gilles "Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

Authors Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki

GPCR Podcast << Back to podcast list Dr. Caron Tribute Part 2 About Marc Caron Dr. He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s Duke Professor until his death. Jie Zhang (1990) Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

GPCR Podcast << Back to podcast list Dr. Caron Tribute Part 1 About Marc Caron Dr. Duke Professor until his death. Lee Limbird (1973) Dr. David Sibley (1988) Memories our panelists shared with us Thanks for listening to this podcast episode Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

GPCR Podcast << Back to podcast list Dr. Raul Gainetdinov About Dr. Raul Gainetdinov Raul R. Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Biology at Duke Gainetdinov was included in the Web of Science (WOS) Highly Cited Researchers (HCR) list, representing GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

GPCR Podcast << Back to podcast list Dr. Caron Tribute Part 3 About Marc Caron Dr. He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s Duke Professor until his death. William Wetsel (current) Memories our panelists shared with us Thanks for listening to this podcast episode Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou

Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis-a form of cell death-and effectively mitigate ferroptosis-associated liver damage Authors Yuelong Yan, Li Zhuang, Boyi Gan Source Contribute to the GPCR News Coming soon Become a Contributor

Kohlenbach LM -2 Zhou Y -1 Marugan JJ -3 Barak LS -1 (senior author) 1-Department of Cell Biology, Duke University Medical Center, Durham, NC 27710. 2-Department of Biology, Duke Trinity College of Arts and minimize side effects for diet-induced metabolic diseases. " Josh Gross on the web Pubmed Google Scholar LinkedIn

GPCR Podcast << Back to podcast list Dr. Richard Premont About Dr. Richard Premont "Dr. Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease. Richard Premont on the web Google Scholar LinkedIn Dr.

GPCR Podcast << Back to podcast list Dr. Richard Premont About Dr. Richard Premont "Dr. Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease. Richard Premont on the web Google Scholar LinkedIn Dr.

GPCR Podcast << Back to podcast list Dr. Richard Premont About Dr. Richard Premont "Dr. Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease. Richard Premont on the web Google Scholar LinkedIn Dr.

GPCR Podcast << Back to podcast list Dr. Richard Premont About Dr. Richard Premont "Dr. Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling pathways in the liver and in liver disease. Richard Premont on the web Google Scholar LinkedIn Dr.