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51 items found for "Zhaotao Wang"
- 🧠Do you want to share your #GPCR knowledge?
🧠Do you want to share your #GPCR knowledge? Come to Dr.
- Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...
HLGR2 RNAi led to a low pupation rate (45.00%), body malformation, abnormal wing expansion, failed cuticle Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.
- Regulators of G-protein signaling: essential players in GPCR signaling
In addition to the RGS domain, RGS proteins also contain a range of other structural motifs that are : Recent studies have revealed that the interaction between RGS proteins and GPCRs is mediated by a range The dysregulation of these proteins has been implicated in a range of diseases, and understanding the Wang, Q., L.Y. Liu-Chen, and J.R. Wang, D., The essential role of G protein-coupled receptor (GPCR) signaling in regulating T cell immunity
- Chemokine receptor-targeted drug discovery: progress and challenges
The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious binding, as well as G-protein coupling or interaction with other signaling molecules (Sohy et al. 2009; Wang protein-protein interactions which are difficult to modulate using small molecules (Sohy et al. 2009; Wang
- Therapeutic validation of an orphan G protein‐coupled receptor
Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders indole‐3‐carbinol, which is present at high levels in some vegetables including broccoli and kale (Wang
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
to predict subtype-selective ligands for dopamine receptors and adenosine receptors (He, Ben, Kuang, Wang & Kong, 2016; Kuang, Feng, Hu, Wang, He & Kong, 2016). 5.
- VAMP2: a crucial player in the delivery of MOR to the synapse
Wang, F., X. Chen, X. Zhang, and L. Ma. 2008.
- Discovery On Target, October 17-20, 2022, Boston, USA
well as target validation strategies for the discovery and development of novel therapeutic agents ranging
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
this review, we have compared expression of GPCR mRNAs in human islets obtained from normal weight range donors, and those with a weight range classified as obese.
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
., Wang, J.K., Bauer, B., Townshend, R.J.L., Hollingsworth, S.A., Olivieri, J.E., Xu, H.E., Sommer, M.E
- MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
cytokines along with their receptors, are involved in various biologic processes and regulation of a wide range
- Verily links up with Sosei Heptares for GPCR drug discovery
recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range
- G protein-coupled receptor signaling: transducers and effectors
"G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including
- Cancer Research UK and Sosei Heptares sign agreement to advance cancer immunotherapy candidate ...
candidate into clinical trials " HTL0039732 is a novel EP4 antagonist with potential to treat a wide range
- Decoding β-Arrestins: from Structure to function
detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang Despite multifocal signaling, recent studies indicate that signaling occurs within a 100 nm range from high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang
- AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., & Vilardaga, J. P. (2009).
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Wang et al. 2009; R. J.
- Overview of adhesion GPCRs self-activation
., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z.,
- Immunomodulatory Role of Neuropeptides in the Cornea
Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,