< GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates Abstract "Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the Sakano, Benjamin P Hurrell, Omid Akbari Tags CB2 , CP: Immunology , CP: Metabolism , ILC2 , T2DM , adipose inflammation , glucose tolerance , immunotherapy , insulin resistance Source Contribute to the GPCR

< GPCR News < GPCRs in Oncology and Immunology Orphan receptor GPR50 attenuates inflammation and insulin Although the mechanism of T2DM is not yet fully known, inflammation and insulin resistance play a central The aim of this study was to investigate the effect of GPR50 on inflammation and insulin resistance in GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells and induced the phosphorylation of AKT

Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2015 - 2018 Postdoctoral fellow, Department of Adipose Research in the Tilley laboratory focuses primarily upon aspects of GPCR regulation of cardiac function, inflammation

signaling pathways in immune cells and insulin-sensitive tissues (liver, pancreas, skeletal muscle, adipose

< GPCR News < GPCRs in Oncology and Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells undergo rapid and extensive metabolic changes during inflammation Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

GPCR News < GPCRs in Oncology and Immunology Efferocytes release extracellular vesicles to resolve inflammation clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation However, whether inflammation resolution is modulated by extracellular vesicles (EVs) and vesicular mediators signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation increase in lesional macrophage efferocytosis efficiency and a decrease in plaque necrosis and lesional inflammation

GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or We further replicated these findings in zebrafish models of islet injury and liver inflammation. Collectively, our results demonstrate that BLT2 mediates macrophage migration during inflammation, which

< GPCR News < GPCRs in Oncology and Immunology CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Inflammation was analysed by measuring the release of inflammatory cytokines. decreased in hDPSCs and, functionally, reexpression of circFKBP5 attenuated LPS-induced apoptosis, inflammation Conclusions: CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation Tags CircFKBP5 , Inflammation , Osteogenic differentiation , Pulpitis , hDPSCs .

GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation A recent Inflammation Somatic Mutation (ISM) theory of cancer posits instead that tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells to engage in tissue inhalation, one of the two types of ISM-required mutations is here hypothesized to block or impede inflammation Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

< GPCR News < GPCRs in Oncology and Immunology Neuroimmune interplay during type 2 inflammation: symptoms mechanisms and therapeutic targets in atopic diseases Published date August 25, 2023 Abstract "Type 2 inflammation consequences of altered neuroimmune activity differ with tissue type and disease and include: skin inflammation diseases and present recent advances in targeted treatment approaches to reduce type 2 inflammation and its related sensory pathologies in diseases associated with type 2 inflammation."

These professional phagocytes are rapidly recruited from the bloodstream to inflamed tissues by chemotactic large family of G protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory insults, as well as for the resolution of inflammation leading to tissue repair. NADPH oxidase advance our understanding of the role of receptor transactivation in the regulation of inflammatory

disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation alterations in macrophage phenotype observed in Gpr101 deficient macrophages were maintained following inflammatory This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced macrophage phenotype and function, modulating key biological activities in both limiting the propagation of inflammation Magdalena B Flak , Duco S Koenis , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation

and Immunology Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation suppressor gene, has received increasing attention owing to its close relationship with oxidative stress and inflammation staining, ELISA, and immunohistochemistry were used to evaluate pathological changes and the degree of inflammation Conclusions: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation

and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation experimental autoimmune encephalomyelitis, an autoimmune disease model for multiple sclerosis, with increased inflammation dendritic cells and that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory

discovered a novel GPCR-dependent atypical kinase activation mechanism that drives vascular edema and inflammation My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

hairpin RNA (shRNA) targeting RGS5 were used to determine the functional significance of RGS5 in vascular inflammation The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs VSMCs treated with BC-CM displayed enhanced pro-inflammatory phenotype and higher adherent with macrophages Conclusions: These findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation to pro-inflammation and induces the pro-inflammatory phenotype of VSMCs that is favorable for tumor

receptors have various physiological and pathophysiological roles in renal acid-base physiology, tissue inflammation high-oxalate intake and 4 days of recovery, renal crystal content, histopathology, filtration function, and inflammation OGR1 KO mice displayed an increased activation of the immune system and a higher production of pro-inflammatory Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease , hyperoxaluria , inflammation

processes that control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation

Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

of G protein-coupled receptor class C group 5 member A (GPRC5A) on lipopolysaccharide (LPS)-induced inflammatory The mRNA and protein levels of GPRC5A in GFs under 1 mg/L LPS-induced GFs inflammatory state were evaluated RT-qPCR was used to detect the gene expression levels of the inflammatory cytokines in GFs induced by Conclusions: GPRC5A expression was upregulated in periodontitis, and GPRC5A knockdown inhibited LPS-induced inflammation Moreover, GPRC5A played a role in inflammation regulation by interacting with NF-κB signaling pathway

Correlation of alterations of GPCR autoantibodies with markers of cardiac or systemic inflammation or cardiac damage, haemodynamics, myocardial histology, or left ventricular inflammation (judged by T2

Brigith Penaranda , Emily Lowry , Roberto P Garofalo , Krishna Rajarathnam Tags GPCR , heterodimer , inflammation

research is on the mechanisms underlying biased agonism at chemokine receptors and how that contributes to inflammation

This protein ligand plays an important role in obesity and inflammatory processes. relevant for its different physiological effects, e. g. the migration of immune cells towards sites of inflammation This may help to develop more potent ligands for the treatment of inflammatory related diseases."

My current research focuses on investigating GPCR signaling and trafficking in the context of inflammation Next Steps Badr will continue focusing his research on GPCRs involved in pain and inflammation during Badr shared his passion for GPCR signalling and regulation, specifically in the context of pain and inflammation

faculty at Duke, with a focus on the mechanisms underlying biased agonism at GPCRs and its contribution inflammation

Animals Alain Garcia De Las Bayonas Critical role for CD97/ADGRE5 in the induction of allergic airway inflammation De Las Bayonas on the web King Lab Critical role for CD97/ADGRE5 in the induction of allergic airway inflammation

receptors, ion channels, and others associated with Wnt, integrin, calcium signaling, growth factors, and inflammation