September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction "The calcium-sensing receptor is a homodimeric class C G protein-coupled It plays a key role in the regulation of human calcium and thus mineral metabolism. nature of interactions between VFT units and HH bundles, and the impacts of heterozygous or homozygous inactivating mutations, which have implications for disorders of calcium metabolism are not yet clearly defined.

are attracted into the synovium to promote remodeling and tissue damage. A higher expression in the mRNA for GPR15 was identified in early RA subjects. GPR15 and GPR15L are present in the synovial tissue of RA patients and GPR15L promotes migration of PBMCs from RA patients and healthy subjects. therapeutic approach in RA."

September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal However, the opening of ion channels mediated by MRGPRB2 activation remains unclear. were correlated with extracellular calcium concentration. The increases in [Ca2+]i and voltage-dependent current caused by MRGPRB2 activation were blocked by U73122 The voltage-dependent current induced by MRGPRB2 was inhibited by calcium-activated chlorine channel

11, 2023 Abstract " The current dogma is that chemoattractants G protein-coupled receptors (GPCRs) activate β phospholipase C (PLCβ) while receptor tyrosine kinases (RTKs) activate γ phospholipase C (PLCγ). stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics of diacylglycerol (DAG) production and calcium response; increased Ras/PI3K/Akt activation; elevated GSK3 phosphorylation and cofilin activation; impaired Tags G protein-coupled receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils

) inflammatory process occurs in the joints where immune cells are attracted into the synovium to promote GPR15 and GPR15L are present in the synovial tissue of RA patients and GPR15L promotes migration of PBMCs from RA patients and healthy subjects. therapeutic approach in RA. and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation

< GPCR News < GPCRs in Oncology and Immunology Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration Published date February 1 Simultaneous activation of CXCR4 and HRH1 synergistically increases calcium flux in MDA-MB-231 cells Synergistic effects on calcium flux and cell migration are inhibited by the Gαi inhibitor pertussis toxin Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress