of Technology in Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Biology at Duke University in North Carolina, USA (1996-2008). Before joining the Department of Cell Biology in 1996 as a postdoc and becoming faculty at Duke in 2000 As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell

Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University Caron received a BS in Biology and BA in Philosophy at Emory University and a PhD at Duke University special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular biology Kathleen Caron on the web UNC-Chapel Hill Department of Cell Biology and Physiology UNC Lineberger Comprehensive

Beatriz Blanco Redondo The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Johannisallee 30, 04103 Leipzig, Germany 2Laboratory of Neurovascular Signaling, Department of Molecular Biology Biology, Department of Biology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany 2 Rudolf Schönheimer Biology at Heinrich Heine University in Düsseldorf, Germany. Willem Berend Post on the web Cell Biology LinkedIn < Previous Session Next Session >

Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit

employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure at the cell

Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular

I completed my Ph.D. in molecular and cell biology at UConn and then joined Addgene as a Quality Control

Stephen, Caron Kathleen M Department of Cell Biology and Physiology at UNC Chapel Hill 111 Mason Farm Van Meir’s research examines how genetic alterations and hypoxia induce changes in cell biology that To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines : Department of Biology, Ashoka University. Currently: University of Leipzig Mansi Tiwari: Department of Biology, Ashoka University.

moved to Mexico City to establish himself as an independent investigator integrating the department of Cell Biology at the Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN as various alternatively spliced isoforms thus potentially resulting in differential modulation of cell

Vanderbilt University, Nashville, TN 37232, USA 4 Peking University, China 5 Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA. She oversaw an increase of the size of the Department, as well as a quintupling of its NIH funding, in transduction and neuroscience, and she has expanded it in the areas of drug discovery and structural biology Stanley Cohen Award “For Research Bringing Diverse Disciplines, such as Chemistry or Physics, to Solving Biology

developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Monserrat Avila Zozaya I did a PhD in cell biology at CINVESTAV, Mexico. About John Azietaku John Teye Azietaku,PhD is a trained pharmacist, holding a Ph.D. in Drug Discovery Biology

developmental biologist with a focus on how planar cell polarity drives complex tissue morphogenesis Jianxiang Xue "I am a postdoctoral researcher working in the Department of Biochemistry and Molecular Biology Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; 2. Current affiliation: Department of Structural Biology, Genentech, South San Francisco, CA, USA" About Biology PhD student " Sheila Ribalta-Mena on the web CINVESTAV ResearchGate LinkedIn GPR110 modulates

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling Date & Time Friday, November 3rd / 1:30 PM Abstract Ribeiro has supervised eleven M.Sc. and six Ph.D. students, as well as five post-doctorate fellows. Nowadays, her research group comprises four undergraduates, two M.Sc., and six Ph.D. students, as well These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington

types (neutrophils, T cells, B cells and dendritic cells) and systematically addressed the functional consequences on GPCR-controlled cell migration and tissue localization. Combined depletion of GRK2 and GRK6 in T cells and B cells shows distinct functional outcomes for (a) one GPCR type in different cell types, and (b) different GPCRs in one cell type. ; GRK; T cells; dendritic cells; immune cell trafficking; leukocytes; neutrophils.

< GPCR News < GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools to control T-47D cells. More than 6000 genes were DE in control T-47D cells upon stimulation with P4 or P4 plus E2. GO analysis revealed seven significantly enriched biological processes affected by PR and associated Many of the genes affected by PR are part of central biological processes of tumorigenesis."

Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells This metallo-protease had no discernible impact on normal cell survival, but it specifically induced apoptosis in ovarian cancer cells. This evoked apoptotic death of the ovarian cancer cells through the intrinsic route. Das, Elizabeth Mahapatra, Saibal Saha, Ananda Pal, Parash Prasad, Amit Pal Tags Cancer , Molecular biology

and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell receptor (GPCR) that is involved in a variety of pathological and physiological processes, while its biological The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations dephosphorylation and nucleus localization of the Yes-associated protein (YAP), and its association with cell Our data collectively demonstrate that BRS3 activation contributes to cell migration through downregulation

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in pH-gradient) is a well-known driver of tumor progression and metastasis. In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery

in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell Results: We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer cell line MDA-MB-231. MDA-MB-231 cells but not in LPA1-deficient cells. have been evidenced across various cell lines.

GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells We have used the method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets. On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206).

News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells High GPR141 messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell myelin oligodendrocyte glycoprotein 35-55-specific T cells. , experimental autoimmune encephalomyelitis , monocytes , myeloid cells .

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Cell lines expressing EBI2 were established by transduction with HIV vectors. The amount of HIV reverse transcripts was similar in cells expressing or not EBI2. Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by The TaqMan probe-based RT-qPCR showed that NPFF and NPFFR2 were expressed in three human EOC cells, CaOV3 In comparison, NPFF and NPFFR2 expression levels were higher in SKOV3 cells than in CaOV3 or OVCAR3 cells Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression

< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction Here, we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer types and identified an enrichment of Gαs-coupled GPCRs on exhausted CD8+ T cells. These include EP2, EP4, A2AR, β1AR and β2AR, all of which promote T cell dysfunction. Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis promotes CD8+ T cell

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes Alejandra Tomas is a molecular cell biologist and Senior Lecturer at the Department of Metabolism, Digestion several years in Switzerland working on the study of membrane trafficking processes in pancreatic beta cells

< GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for 2a receptor (A2aR), a typical GPCR with a high affinity for adenosine, is widely expressed on immune cells Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) We hypothesize that blocking A2aR on LUAD cells will inhibit the role of TAMs and control tumor growth Constructing models of TAMs and LUAD mice, we find that A2aR highly expressed on LUAD cells promotes

induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells signaling molecules and the phosphatidylinositol, Ras, MAPK, and PI3 kinase pathways, leading to T cell This may explain the inhibitory impact on IL-2 production in hM3Dq/β1T cells. that activating the pAKT pathway is critical for IL-2 production in T cells." Tags GPCR; T cells; muscarinic receptor; signaling.

Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell A single-cell analysis was used to assess GNAI3 expression in GBM. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR