previously solved class A GPCR-Gi complex structures is observed in CX3CR1, which may correlate with three cholesterol Thus, our data deepen the understanding of cholesterol modulation in GPCR (G protein-coupled receptor

We considered whether cholesterol, a prominent component of the plasma membrane, limits the ability of Here, we present comparative MSM analyses of 150-μs simulations of opsin in cholesterol-free and cholesterol-rich Our analyses reveal that cholesterol inhibits phospholipid scrambling by occupying the TM6/7 interface

October 2022 Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking Cholesterol is a key constituent of higher eukaryotic membranes and is believed to contribute to the To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking depletion, irrespective of the method of cholesterol depletion. accompanied by a reduction in diffusion coefficient for chronic cholesterol depletion.

for Cellular and Molecular Biology at Hyderabad, India, where he studied the interaction of membrane cholesterol